舍曲林对慢性心力衰竭患者合并焦虑抑郁症状的疗效观察

Observation of Sertraline in Treatment of Chronic Heart Failure Patients with Anxiety and Depression Symptoms

目的观察慢性心力衰竭急性加重期患者焦虑抑郁发病情况及舍曲林对焦虑抑郁症状患者的疗效。方法选取2017年1月至2018年7月南通市第四人民医院收治的99例慢性心力衰竭急性加重期患者采用焦虑自评量表(SAS)、抑郁自评量表(SDS)进行问卷调查,了解慢性心力衰竭急性加重期患者焦虑抑郁的发病情况,同时对其中52例有焦虑抑郁症状的慢性心衰患者随机分成治疗组和对照组,每组26例。两组均给予慢性心衰针对性治疗,治疗组同时给予抗抑郁药-选择性5-羟色胺再摄取抑制剂,如帕罗西汀、舍曲林、艾司西酞普兰等,4周后对两组患者再次进行SAS、SDS评分。结果慢性心力衰竭患者发生焦虑抑郁的概率高,对慢性心力衰竭合并焦虑抑郁症状患者进行药物干预后SAS、SDS评分明显低于对照组,差异具有统计学意义(P<0.05)。结论慢性心力衰竭易合并焦虑抑郁情绪,早期干预对于慢性心衰预后有明显改善。

Objective To understand the incidence of anxiety and depression in patients with acute exacerbation of chronic heart failure and to observe the therapeutic effect of sertraline on patients with anxiety and depression symptoms.Methods To observe the incidence of anxiety and depression in patients with acute exacerbation of chronic heart failure and the effect of sertraline on anxiety and depression.Methods between January 2017 and July 2018 in nantong,the fourth people's hospital treated 99 cases of chronic heart failure in patients with acute aggravating period by the self-assessment lists of anxiety(SAS),depression self rating scale(SDS),the questionnaire survey to understand the chronic heart failure in patients with acute aggravating period of anxiety depression incidence,at the same time of 52 cases with anxiety depression symptoms of chronic heart failure patients were randomly divided into treatment group and control group,26 cases in each group.Both groups were given targeted treatment for chronic heart failure.The treatment group was also given antidepressant-selective serotonin re-intake agents,such as paroxetine,sertraline,citalopram and so on.After 4 weeks,SAS and SDS were scored again in the two groups.Results The incidence of anxiety and depression in patients with chronic heart failure is high.The scores of SAS and SDS in patients with chronic heart failure and anxiety and depression symptoms after drug intervention are significantly lower than those in the control group.The difference is statistically significant(P<0.05).Conclusion Chronic heart failure is prone to anxiety and depression.Early intervention can significantly improve the prognosis of chronic heart failure.