来曲唑联合坤泰胶囊治疗克罗米芬抵抗的PCOS不孕患者疗效

Effect of Letrozole Combined with Kuntai Capsule on PCOS Infertility Patients with Clomiphene Resistance

目的探析来曲唑(LE)联合坤泰胶囊治疗克罗米芬(CC)抵抗的多囊卵巢综合征(PCOS)不孕症患者的治疗效果。方法选取江苏省宿迁市泗洪县中心医院于2017年5月至2018年10月在不孕不育门诊收治的PCOS不孕症具有CC抵抗的69例患者作为研究对象,进行回顾性研究,按照治疗方式的不同分为对照组与观察组。其中对照组30例,给予LE治疗。观察组39例,在LE治疗的基础上联合坤泰胶囊予以综合治疗。观察两组患者用药后的排卵情况(成熟卵泡数、排卵子宫内膜厚度)以及妊娠情况。结果两组患者总妊娠率比较,差异无统计学意义(51.28%vs.50.00%,P>0.05)。观察组的成熟卵泡数、排卵子宫内膜厚度均显著大于对照组(P<0.05)。结论LE联合坤泰胶囊治疗PCOS不孕症具有CC抵抗的患者,可改善子宫内膜的容纳性,有利于提高胚胎着床,提高临床妊娠率,是一种行之有效的促排卵辅助药物。

Objective To investigate the therapeutic effect of letrozol(LE)combined with Kuntai Capsule on polycystic ovary syndrome(PCOS)infertility patients with clomiphene(CC)resistance.Methods Totally 69 PCOS infertility patients with CC resistance who were admitted to the Infertility Clinic of Central Hospital of Sihong County from May 2017 to October 2018 were selected and divided into the control group(30 cases)and observation group(39 cases).The control group was treated with LE.The observation group was treated with LE combined with Kuntai Capsule.The ovulation(number of mature follicles,endometrial thickness of ovulation)and pregnancy were observed in two groups.Results There was no significant difference in pregnancy rate between the two groups(51.28%vs.50.00%,P>0.05).The number of mature follicles and ovulation endometrial thickness in the observation group were significantly better than those in the control group(P<0.05).Conclusion LE combined with Kuntai Capsule,as an effective aid to ovulation,can improve endometrial receptivity,embryo implantation and clinical pregnancy rate in the treatment of PCOS infertility patients with CC resistance.