凝血酶联合奥曲肽治疗肝硬化合并上消化道出血的疗效评价

Effect of Thrombin Combined with Octreotide in Treatment of Cirrhosis with Upper Gastrointestinal Hemorrhage

目的评价凝血酶联合奥曲肽治疗肝硬化合并上消化道出血的疗效。方法选取2015年12月至2019年1月陕西省商洛市商南县医院收治的100例肝硬化合并上消化道出血患者为观察对象,根据信封法分为两组,每组50例。对照组行奥曲肽治疗,试验组在此基础上行凝血酶治疗。对比两组疗效、止血时间及肝功能指标。结果试验组患者临床疗效为96.00%,对照组患者临床疗效为82.00%,试验组患者平均止血时间(17.56±5.21)h,对照组患者平均止血时间(24.95±5.45)h;治疗后,试验组患者谷草转氨酶(AST)、谷丙转氨酶(ALT)、总胆红素(TBil)水平优于对照组,组间比较差异有统计意义(P<0.05)。结论肝硬化合并上消化道出血患者实施凝血酶联合奥曲肽治疗,对于临床疗效的提升具有重要价值,且可提升止血效率,改善肝功能。

Objective To evaluate the effect of thrombin combined with octreotide in the treatment of cirrhosis with upper gastrointestinal bleeding.Methods A total of 100 patients with cirrhosis and upper gastrointestinal hemorrhage were included from December 2015 to January 2019.The patients were divided into two groups by the envelope method,with 50 cases in each group.The control group was treated with octreotide.The experimental group was treated with thrombin therapy.The curative effect,hemostasis time and liver function index were compared between the two groups.Results The clinical efficacy of the experimental group was 96.00%.The clinical efficacy of the control group was 82.00%.The average hemostasis time(17.56±5.21)h in the experimental group and the average hemostasis time in the control group(24.95±5.45)h.After the treatment,the experimental group The levels of AST,ALT and TBil were better than the control group,with statistical significance(P<0.05).Conclusion The treatment of thrombin combined with octreotide in patients with cirrhosis and upper gastrointestinal hemorrhage is of great value for the improvement of clinical efficacy,and can improve hemostasis efficiency and improve liver function.