辨证论治大肠癌围手术期48例

Treating 48 Cases of Colorectal Cancer During Perioperative Period by Syndrome Differentiation and Treatment

目的:观察中医辨证治疗大肠癌围手术期患者的临床疗效。方法:将96例患者按就诊顺序随机分为观察组、对照组,每组48例2组均给予围手术期常规治疗,观察组同时给予中医辨证论治。比较2组临床疗效、术后恢复情况、术后不良反应、生活质量及生存率。结果总有效率观察组为97.92%,对照组为87.5%,观察组明显高于对照组,差异有统计学意义(P<0.05)。随访12~36个月术后1年生存率、复发率、不良反应发生率观察组分别为93.75%(45/48)、2.08%(1/48)、8.33%(4/48)。对照组分别为83.33%(40/48)、6.25%(3/48)、22.92%(11/48),2组比较差异均有统计学意义(P<0.05)。胃肠功能恢复时间、术后住院时间观察组少于对照组,差异有统计学意义(P<0.05)。KPS评分治疗前2组相比,差异无统计学意义(P> 0.05);与治疗前相比,2组论治后1个月、3个月、6个月KPS评分明显上升,并且相同时间点观察组高于对照组(P<0.05)。结论:辨证论治围手术期大肠癌患者,可提高临床疗效,加快患者恢复,提高术后生活质量延长生存期。

Objective:To observe curative effects of TCM syndrome differentiation and treatment for the patients with colorectal cancer during perioperative period.Methods:A total of 96 patients were allocated to the observation group and the control group according to the visiting order,48 cases each group,both groups accepted conventional therapy during perioperative period,the observation group were given TCM syndrome differentiation and treatment.To compare therapeutic effects,postoperative rehabiliation conditions,postoperative adverse reaction,quality of life and survical rate between both groups.Results:Total effective rate of the observation group was97.92%,higher than 87.5% of the control group notably,and the difference had statistical meaning(P<0.05).After followed for 12 to 36 months,postoperative one-year survival rate,relapse rate,adverse reaction incidence of the observation group were 93.75%(45/48),2.08%(1/48) and 833%(4/48),and these of the control group were 8333%(40/48),6.25%(3/48) and 22.92%(11/48) respectively,and the difference was statistically significant(P<0.05).The observation group was less than the control group in the recovery time of gastrointestinal function and postoperative hospitalization time,and the difference had statistical meaning(P<0.05).The difference had no statistical meaning in KPS scores between both groups before treating(P>0.05);compared with before treating,KPS scores rose apparently when both groups were treated for one month,three months and six months,and the observation group was higher than the control group at the same time point(P<0.05).Conclusion:TCM syndrome differentiation and treatment for the patients with colorectal cancer during perioperative period could raise curative effects,accelerate the recovery,prolong the survival period and lift postoperative quality of life.