健脾和胃辨证中药方治疗妇科肿瘤患者化疗后消化道副反应的效果

Effect of traditional Chinese medicine prescription for spleen and stomach syndrome differentiation on the side effects of digestive tract in patients with gynecological tumor after chemotherapy

目的探讨健脾和胃辨证中药方治疗妇科肿瘤患者化疗后消化道副反应的效果,为临床诊疗提供依据。方法选取宝鸡市中心医院2016年1月至2018年5月收治的妇科肿瘤化疗患者120例进行研究。按照随机数表法将患者分为对照组和观察组,每组60例。对照组采取常规西药治疗一个疗程,观察组通过健脾和胃辨证中药方治疗一个疗程。疗程结束一周后,比较两组患者治疗后的临床疗效、消化道副反应发生率,并通过生命质量测定量表(QLQ-C30量表)比较两组患者治疗后的生活质量。结果观察组患者的治疗总有效率为95.00%,明显高于对照组的71.67%,差异有统计学意义(P<0.05);观察组和对照组患者治疗后的恶心呕吐(40.00%vs 65.00%)、腹泻(45.00%vs 63.33%)、食欲减退(16.67%vs 33.33%)、味觉异常(36.67%vs 71.67%)、便秘(38.33%vs 56.67%)及胃胀胃痛(36.67%vs 55.00%)的发生率比较,观察组明显低于对照组,差异均有统计学意义(P<0.05);观察组和对照组患者的情绪功能[(60.42±8.26)分vs(47.29±4.32)分]、角色功能[(60.84±9.47)分vs(54.21±5.37)分]、躯体功能[(67.53±11.68)分vs(56.37±7.24)分]、社会功能[(59.52±8.73)分vs(50.25±7.38)分]评分比较,观察组明显高于对照组,差异均有统计学意义(P<0.05)。结论健脾和胃辨证中药方可有效降低妇科肿瘤化疗后患者的消化道毒副反应发生率,改善患者生活质量,值得临床推广应用。

Objective To explore the therapeutic effect of traditional Chinese medicine prescription for spleen and stomach syndrome differentiation,and to provide basis for clinical diagnosis and treatment.Methods A total of 120 patients with gynecological cancer treated in Baoji Central Hospital from January 2016 to May 2018 were selected.According to the random number table method,the patients were divided into two groups,with 60 patients in each group.The control group was treated with conventional western medicine for one course,and the observation group was treated with traditional Chinese medicine prescription for spleen and stomach syndrome differentiation for one course.One week after treatment,the clinical efficacy and the incidence of gastrointestinal side effects of the two groups were compared,and the quality of life of the two groups after treatment was compared by the quality of life measurement scale(QLQ-C30 scale).Results The total effective rate of treatment in the observation group was 95.00%,which was significantly higher than 71.67%of the control group(P<0.05).The incidence of nausea and vomiting(40.00%vs 65.00%),diarrhea(45.00%vs 63.33%),loss of appetite(16.67%vs 33.33%),abnormal taste(36.67%vs 71.67%),constipation(38.33%vs 56.67%),and the incidence of bloating and stomach pain(36.67%vs 55.00%)were significantly lower in the observation group than in the control group(P<0.05).The emotional function,role function,body function,and social function in the observation group were significantly higher than those in the control group(P<0.05):(60.42±8.26)points vs(47.29±4.32)points;(60.84±9.47)points vs(54.21±5.37)points;(67.53±11.68)points vs(56.37±7.24)points;(59.52±8.73)points vs(50.25±7.38)points.Conclusion The traditional Chinese medicine for strengthening the spleen and stomach can effectively reduce the incidence of gastrointestinal side effects in patients with gynecological tumors after chemotherapy,and improve the quality of life of patients.It is worthy of clinical application.