中枢神经系统肾素（原）受体参与高血压发病机制的研究进展

Progress of Central Nervous System(Pro) Renin Receptor in the Pathogenesis of Hypertension

肾素(原)受体是由ATP6AP2基因编码、350个氨基酸组成的Ⅰ型单次跨膜蛋白,广泛存在于多种组织器官中,并在大脑中高度表达。中枢神经系统肾素(原)受体与高血压密切相关,并通过促进血管紧张素Ⅱ形成的肾素-血管紧张素系统机制以及其他非肾素-血管紧张素系统机制参与血压调节。中枢神经系统肾素(原)受体有可能成为高血压治疗新靶点。

The(pro) renin receptor is a type I single transmembrane protein composed of 350 amino acids and encoded by the ATP6 AP2 gene. It is widely distributed in various tissues and organs and is highly expressed in the brain. The central nervous system(pro) renin receptor is closely related to hypertension, and are involved in blood pressure regulation through reninangiotensin system(RAS) dependent signaling pathway and other signaling pathways. The central nervous system(pro) renin receptor may become a new target for hypertension treatment.