口腔扁平苔藓实验模型建立的研究进展

Research progress on experimental model establishment of oral lichen planus

口腔扁平苔藓是一种最常见的口腔黏膜慢性炎症性疾病,临床上缺乏有效的治疗措施。寻找和建立合适的实验模型对开展口腔扁平苔藓诊治研究有着重要的意义,但因口腔扁平苔藓的发病原因和机制未明,给实验模型的建立带来困难,是目前口腔学者面临的难题之一。迄今为止,国内外尚未建立完善的口腔扁平苔藓动物模型,而相关细胞模型已较为成熟,本文就目前口腔扁平苔藓实验模型的研究进展进行综述。

Oral lichen planus is one of the most common chronic inflammatory diseases of oral mucosa, which lacks effective treatment in clinic. Finding and establishing an appropriate experimental model is of great significance for the diagnosis and treatment of oral lichen planus. However, due to the unclear pathogenesis and mechanism, it is difficult to establish an experimental model, which is one of the difficulties faced by stomatologists at present. Up to now, there is no perfect animal model of oral lichen planus at home and abroad, while the related cell model has been mature. This article reviews the current research progress of experimental models of oral lichen planus.