基于多组学技术的农药致毒机制研究进展

Advances in pesticide poisoning mechanism based on multi-omics

中国作为农业大国,国家的安宁稳定与粮食生产及安全密不可分。农药使用在保障农作物高产稳产的同时,其与环境安全和食品安全的矛盾也越来越突出,因而对农药风险评估与管理的研究正日益受到研究者的关注。多组学技术已在生命科学及医药学等领域得到迅猛发展,但其在农药风险评估和致毒机制研究中的应用尚处于起步阶段,未来发展空间较大。文章重点比较分析了基因组学、蛋白质组学、代谢组学及表观遗传学等组学方法在农药致毒分子机制研究方面的进展及优劣,根据研究发现的各种关键性生物标志物及其重要调控信号路径,综合探讨了基于多组学技术的农药对非靶标生物的毒性作用机制,以及多组学技术在农药风险管理中的应用。

China is a big agricultural country.The food supply stability is heavily relied on the agriculture advancement.Despite the usage of pesticides has ensured the stable crop yield,the increasing usage of pesticide has resulted in long-term negative impacts on the environmental and food safety.Thus,the risk assessment and management of pesticides have called for increasing attention of researchers.Multi-omics is a promising tool for identifying the mode of action of bioactive compounds in pharmaceutical industry.However,few studies have applied this approach in the risk assessment and mechanisms of toxic in pesticides.In this review,the progress in the mode of toxic action identification of the pesticides by various omics approaches has been summaried.Based on the previous research,some key biomarkers and their corresponding regulatory pathways were identified,and the potential mode of toxic actions and application of risk management of pesticides were explored.