齐拉西酮致血小板减少症1例

Thrombocytopenia caused by ziprasidone:a case report

本文目的是通过报道1例齐拉西酮致血小板减少症,以引起临床对此不良反应的关注。1例29岁女性精神分裂症患者既往无血小板减少症病史及家族史,用药前检查血小板水平正常,在应用齐拉西酮治疗9天后出现腹部及双上肢皮肤瘀斑,并逐渐增多,延展至臀部及下肢等处,检查血小板降至1×10^9/L,遂停用齐拉西酮,输注单采血小板,加用咖啡酸片等治疗,血小板逐渐回升,8天后恢复正常,皮肤瘀斑消退。提示系齐拉西酮所致血小板减少症。

A case of thrombocytopenia caused by ziprasidone is reported in this paper,so as to arouse clinical concerns on this adverse reaction.A 29-year-old female schizophrenic patient,who had no medical or family history of thrombocytopenia and normal platelet level before medication,developed ecchymosis on the skin of abdomen and upper limbs after treatment for 9 days,which gradually worsened and extended to the skin of buttocks and lower limbs.Examination showed that the patient's platelet decreased to 1×109/L.Ziprasidone was discontinued clinically,and the treatments of platelet infusion combined with caffeic acid tablets were applied.Then the platelets level gradually recovered,and the skin returned to normal 8 days later.These results indicate thrombocytopenia is caused by ziprasidone.