穿透素3在社区获得性肺炎患儿中的变化及意义

Changes and significance of pentamerin 3 in children with community acquired pneumonia

目的探讨穿透素3(PTX3)在社区获得性肺炎患儿中的变化及意义。方法选取100例社区获得性肺炎患儿作为观察组,根据患儿病情程度分为轻度组和重度组,另外选取同期健康体检儿童50名作为对照组,比较健康儿童体检时以及观察组入院时肿瘤坏死因子(TNF-α)、C反应蛋白(CRP)、降钙素原(PCT)和PTX3水平,监测所有患儿入院7 d内的PTX3水平变化。结果入院时,重度组和轻度组患儿TNF-α、CRP、PCT、PTX3水平明显高于对照组,差异均有统计学意义(t分别=22.25、16.67、15.03、9.14、26.74、19.40、42.31、24.79,P均<0.05),且重度组患儿TNF-α、CRP、PCT、PTX3水平明显高于轻度组,差异均有统计学意义(t分别=6.63、10.98、14.88、24.76,P均<0.05);PTX3水平与脉搏血氧饱和度、动脉氧分压(PaO2)呈负相关(r分别=-0.26、-3.02,P均<0.05),与呼吸频率、PCT、TNF-α水平呈正相关(r分别=0.38、0.31、0.29,P均<0.05);治疗期间PTX3水平呈逐渐降低趋势(F=15.01,P均<0.05)。结论PTX3随着患儿病情加重而升高,可作为社区获得性肺炎患儿病情评估的指标之一。

Objective To investigate the changes and significance of pentamerin 3(PTX3)in children with community acquired pneumonia.Methods A total of 100 children with community-acquired pneumonia were enrolled as the observation group and divided into mild group and severe group according to the severity of the disease.Totally 50 healthy children in the same period were selected as the control group.The levels of TNF-α,CRP,PCT and PTX3 between two groups were compared,and the PTX3 level in children with community acquired pneumonia was observed within 7 days after admission.Results The levels of TNF-α,CRP,PCT and PTX3 in the severe group and mild group were significantly higher than those in the control group(t=22.25,16.67,15.03,9.14,26.74,19.40,42.31,24.79,P<0.05).The levels of TNF-α,CRP,PCT and PTX3 in the severe group were significantly higher than those in the mild group(t=6.63,10.98,14.88,24.76,P<0.05).The level of PTX3 was negatively correlated with pulse oxygen saturation and PaO2(r=-0.26,-3.02,P<0.05),while positively correlated with respiratory rate,PCT and TNF-α(r=0.38,0.31,0.29,P<0.05).The PTX3 level decreased gradually during treatment(F=15.01,P<0.05).Conclusion PTX3 level is positively related to the severity of the disease,which be used as an indicator for disease diagnosis and disease assessment in children with community acquired pneumonia.