肿瘤坏死因子-α、血管紧张素Ⅱ和内毒素水平与慢性肝衰竭患者并发Ⅰ型肝肾综合征的相关性分析

Correlation between tumor necrosis factor-α, angiotensin Ⅱ, endotoxin levels and patients with chronic liver failure complicated with type Ⅰ hepatorenal syndrome

目的探讨肿瘤坏死因子-α(TNF-α)、血管紧张素Ⅱ(AngⅡ)和内毒素水平与慢性肝衰竭(CLF)患者并发Ⅰ型肝肾综合征(HRS)相关性。方法选取2014年1月~2018年12月我院收治的30例CLF患者作为对比组,选取同期收治的30例CLF并发Ⅰ型HRS患者的临床资料作为实验组,比较两组的TNF-α、AngⅡ及内毒素水平,采用Pearson相关系数分析TNF-α、AngⅡ及内毒素与Ⅰ型HRS的相关性。结果实验组TNF-α、AngⅡ和内毒素水平均高于对比组,差异有统计学意义(P<0.05);TNF-α、AngⅡ、内毒素水平和Ⅰ型HRS均成正相关关系(r=0.627、0.689、0.713,P<0.05)。结论CLF并Ⅰ型HRS患者的TNF-α、AngⅡ及内毒素水平均偏高,且成正相关关系,能够为HRS的预警提供依据。

Objective To explore correlation between tumor necrosis factor-α(TNF-α),angiotensinⅡ(AngⅡ),endotoxin levels and patients with chronic liver failure(CLF)complicated with type I hepatorenal syndrome(HRS).Methods Clinical data of 30 CLF patients who were admitted to our hospital from January 2014 to December 2018,were selected and they were enrolled as control group.30 patients with CLF and type I HRS who were admitted in the same period were enrolled as experimental group.The levels of TNF-α,AngⅡand endotoxin were compared between the two groups.Pearson correlation coefficient analysis was performed to analyze correlation between TNF-α,AngⅡ,endotoxin and type I HRS.Results The levels of TNF-α,AngⅡand endotoxin in the experimental group were higher than those in the control group(P<0.05).There was positive correlation between TNF-α,AngⅡ,endotoxin levels and type I HRS(r=0.627,0.689,0.713,P<0.05).Conclusion The levels of TNF-α,AngⅡand endotoxin in patients with CLF and type I HRS are high,and they were positively correlated.They can provide effective basis for early warning of HRS.