前列地尔联合依达拉奉治疗急性脑梗死合并高血压患者的临床效果

Clinical effect of Alprostadil combined with Edaravone in the treatment of acute cerebral infarction with hypertension

目的探讨前列地尔联合依达拉奉治疗急性脑梗死合并高血压患者的临床效果。方法选取2016年1月~2018年12月我院收治的68例急性脑梗死合并高血压的患者作为研究对象,按照简单随机抽样法将其分为观察组与对照组,每组34例。对照组患者选用依达拉奉治疗,观察组患者在对照组基础上加用前列地尔治疗,两组患者均治疗2周。比较两组患者治疗前后的凝血酶原时间(PT)、部分凝血活酶时间(APTT)以及D-二聚体(D-D)、肌钙蛋白I(cTnI)、同型半胱氨酸(Hcy)、S100B蛋白表达水平及患者神经功能情况[美国国立卫生研究院卒中量表(NIHSS)]。结果治疗后,观察组患者的PT、APTT短于对照组,D-D水平低于对照组(P<0.05);观察组患者的cTnI以及Hcy表达水平低于对照组(P<0.05);观察组NIHSS评分、S100B蛋白表达水平低于对照组(P<0.05)。结论使用前列地尔联合依达拉奉治疗急性脑梗死合并高血压患者可以有效改善患者凝血功能,降低血浆cTnI、Hcy的表达水平,改善神经功能,值得临床应用推广。

Objective To explore the clinical effect of Alprostadil combined with Edaravone in the treatment of acute cerebral infarction with hypertension.Methods A total of 68 patients with acute cerebral infarction and hypertension who were admitted to our hospital from January 2016 to December 2018 were enrolled as the objects.They were divided into observation group and control group by simple random sampling method,34 cases in each group.The control group was treated with Edaravone.On this basis,observation group was additionally treated with Alprostadil.Both groups were treated for 2 weeks.The prothrombin time(PT),partial thromboplastin time(APTT),D-dimer(D-D),troponin I(cTnI),homocysteine(Hcy),S100 B protein expression level and neurological function(national institutes of health stroke scale[NIHSS])of the two groups were compared before and after treatment.Results After treatment,PT and APTT in observation group were shorter than those in control group,while D-D was lower than that in control group(P<0.05).The expression levels of cTnI and Hcy in observation group were lower than those in control group(P<0.05).NIHSS score and expression level of S100 B protein in observation group were lower than those in control group(P<0.05).Conclusion Alprostadil combined with Edaravone in treatment of patients with acute cerebral infarction and hypertension can effectively improve coagulation function,reduce expression of plasma cTnI and Hcy,and improve nerve function,and it is worthy of clinical application and promotion.