中老年人大肠癌基因易感性研究进展

Research progress on genetic susceptibility of colorectal cancer in middle-aged and elderly people

大肠癌是全世界因病致死的第三大原因。大肠癌的致病因素有很多,而且富有多样化,随着人平均寿命的增加,中老年人大肠癌发病率和死亡率也在呈上升趋势,因此早期筛查出有结直肠癌风险的个体,可以对该疾病实施适当的治疗和管理,这可能降低大肠癌发病率和死亡率,有利于减轻社会的经济负担,对改善患者预后有很大帮助。近年来,遗传易感性因素在调节大肠癌易感性中的作用越来越明显。本文综述了近年来与大肠癌相关的基因多态性的研究进展,基因多态性有望作为大肠癌易患性的生物标志物。

Colorectal cancer is the third leading cause of death worldwide.There are many pathogenic factors of colorectal cancer,and they are rich in diversification.With the increase of life expectancy,the incidence and mortality of colorectal cancer in the elderly are also on the rise.Therefore,individuals at risk of colorectal cancer can be diagnosed early and treated and managed appropriately.This may reduce the incidence and mortality of colorectal cancer and help to reduce the negative economic impact of society.Duan is very helpful to improve the prognosis of patients.This article reviews the recent advances in gene polymorphisms associated with colorectal cancer.The genetic polymorphism may be used as a biomarker of susceptibility to colorectal cancer.