TRIB3与疾病相关性研究进展

Current study of TRIB3 and diseases

TRIB3为假激酶,在真核细胞中能与多种蛋白结合,介导糖尿病、癌症、心血管疾病、神经系统疾病的发生发展,但它们的相互调控关系及分子机制尚未阐明。该文将对TRIB3参与的疾病及调控通路进行综述,旨在为寻找糖尿病、癌症、心血管疾病和神经系统疾病的发病共同分子机制提供线索和依据。

TRIB3 is a pseudokinase that binds to a variety of proteins in eukaryotic cells and mediates the development of diabetes,cancer,cardiovascular diseases and nervous system diseases, but their mutual regulatory relationship and molecular mechanisms have not yet been elucidated.This article reviews the diseases and regulatory pathways involved in TRIB3,in order to provide clues and evidence for finding common molecular mechanisms of the pathogenesis of diabetes,cancer and cardiovascular diseases.