摘要
目的为探讨蒙药忠伦-5治疗类风湿关节炎的作用机制,进行了网络药理学研究。方法通过多种数据库获得蒙药忠伦-5单味药的成分及靶点信息,对这些靶点进行筛选,得到成分治疗类风湿关节炎作用的靶点,并对靶点进行分析在治疗类风湿关节炎中的意义。结果筛选得到蒙药忠伦-5治疗类风湿关节炎的靶点90个,网络分析结果表明蒙药忠伦-5参与126个生物过程,调节RAS、PPAR、自噬、JAK-STAT、肿瘤坏死因子等43条与类风湿关节炎密切相关的信号通路。确定了忠伦-5治疗类风湿关节炎的关键靶点有MAPK9、MAPK8、Akt1、MAPK14、STAT1、STAT3和Bcl-2。结论通过网络药理学的方法预测了蒙药忠伦-5的治疗靶点,也反映出其多靶点、多途径的作用特点,为后续研究开发工作提供了理论线索。
Aim To explore the mechanism of Mongolian medicine Zhonglun-5 in the treatment of rheumatoid arthritis via carrying out the network pharmacologyresearch.Methods Through various databases,we obtained the composition information and targets of Mongolian medicine Zhonglun-5,and perform multiple ana-lyses on these targets.Then,combined with theabove results,we concluded the significance of targets in anti-rheumatoid arthritis.Results Ninety targets for the treatment of rheumatoid arthritis with Mongolian medicine Zhonglun-5 were screened.The network analysis showed that Zhonglun-5 participated in 126 biological processes andgets 43 pathways for regulating RAS,PPAR,autopagy,JAK-STAT,tumor necrosis factor,etc.which were closely related with rheumatoid arthritis.Itwas confirmed that the key targets of anti-rheumatoid arthritis were MAPK9,MAPK8,Akt1,MAPK14,STAT1,STAT3 and Bcl-2.Conclusions The therapeutic target of Mongolian medicine Zhonglun-5 is predicted by network pharmacology,which also reflected its multi-target and multi-channel characteristics,and provided a theoretical clue for the follow-up research anddevelopment of Zhonglun-5.
作者
付旭阳
高丽
吕宏
侯秋丽
陈金双
孔令雷
石瑞丽
FU Xu-yang;GAO Li;LYU Hong;HOU Qiu-li;CHEN Jin-shuang;KONG Ling-lei;SHI Rui-li(Dept of Physiology,Baotou Medical College,Baotou,Inner Mongolia 014040,China;Institute of Neuroscience,Baotou Medical College,Baotou,Inner Mongolia 014040,China;Modern Research Center of Traditional Chinese Medicine,Shanxi University,Taiyuan 030006,China;Dept of Anesthesia,Guangdong General Hospital,Guang dong Academy of Medidal Science,Guangzhou 510080,China;Dept of Anesthesiology,First Hospital of Inner Mongolia Prison Administration,Huhhot 010000,China;School of Anesthesia,Baotou Medical College,Baotou,Inner Mongolia 014040,China;Beijing Key Lab of Drug Targets Identification and Drug Screening,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China)
出处
《中国药理学通报》
CAS
CSCD
北大核心
2020年第1期127-134,共8页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助项目(No 81960734)
北京市自然科学基金面上项目(No 7182113)
内蒙古自然科学基金资助项目(No 2017MS0808)
内蒙古自治区高等学校科学研究资助项目(No NJZC17244)
内蒙古自治区科技计划项目(No 20090501)
关键词
蒙药
忠伦-5
类风湿关节炎
网络药理学
有效成分
分子对接
Mongolian medicine
Zhonglun-5
rheumatoid arthritis
network pharmacology
active ingredient
molecular docking
