高浓度羟基乙酸治疗毛周角化病的临床疗效

Efficacy of high concentration of glycolic acid for perifollicular keratosis

目的:评价高浓度羟基乙酸治疗毛周角化病的有效性及安全性。方法:25例受试者选取具有典型皮损的区域,在受试部位均匀涂抹高浓度的羟基乙酸,每20 d重复治疗1次,共4次,并在第20、40、60、80天分别对患者毛囊角化性丘疹进行计数,毛囊口红斑及色素水平进行测量,进行疗效及安全性评估。结果:受试部位第20天,40天,60天及80天角化性丘疹治疗有效率分别为8%,12%,36%,60%,与治疗前相比,差异均有统计学意义(P<0.05);皮肤中黑素含量及皮肤亮度在第40天,60天及80天与对照组差异有统计学意义(P<0.05);皮肤血红素含量在第60天及80天与治疗前相比差异有统计学意义(P<0.05)。结论:高浓度羟基乙酸能显著有效毛周角化病的粗糙程度及毛囊口色素沉着过度,且较为安全。

Objective:To evaluate the efficacy and safety of high concentration of glycolic acid in the treatment of perifollicular keratosis. Methods: Typical skin lesions of perifollicular keratosis in 25 subjects were treated topically with high concentration of glycolic acid once every 20 days for 4 times. The number of skin lesions was counted on days 20, 40, 60, and80, respectively. Follicular hemoglobin and melanin content were also measured. Results: Marked reductions in the number of lesions were observed on days 20, 40, 60, and 80(8%, 12%, 36%, and 60%, respectively, P<0.05 vs. pretreatment). Moreover, both melanin content and skin brightness differed significantly on days 40, 60, and 80 in comparison to the controls(P<0.05 vs. controls). In addition, cutaneous hemoglobin content significantly decreased from pretreatment on days 60 and 80 days(P<0.05 vs. pretreatment). Conclusion: High concentration of glycolic acid is effective and safe for perifollicular keratosis, including improving skin roughness and pigmentation.