雷贝拉唑联合克拉霉素、阿莫西林治疗良性胃溃疡的疗效研究

Efficacy of rabeprazole combined with clarithromycin and amoxicillin in the treatment of benign gastric ulcer

目的:探讨雷贝拉唑联合克拉霉素、阿莫西林治疗良性胃溃疡的疗效。方法:2018年1月-2019年1月收治良性胃溃疡患者90例,随机分为两组,各45例。对照组使用奥美拉唑联合克拉霉素、阿莫西林治疗;观察组使用雷贝拉唑钠肠溶片联合克拉霉素、阿莫西林治疗。比较两组治疗效果。结果:观察组腹痛缓解率、治疗总有效率明显高于对照组,腹痛缓解时间明显短于对照组,不良反应发生率及复发率均明显低于对照组,差异有统计学意义(P<0.05)。结论:雷贝拉唑联合克拉霉素、阿莫西林治疗良性胃溃疡疗效显著,能有效抑制幽门螺杆菌,提高腹痛缓解效果,且不良反应少,复发率低。

Objective:To explore the efficacy of rabeprazole combined with clarithromycin and amoxicillin in the treatment of benign gastric ulcer.Methods:From January 2018 to January 2019,90 patients with benign gastric ulcer were selected and randomly divided into two groups of 45 cases in each.The control group was treated with omeprazole combined with clarithromycin and amoxicillin,and the observation group was treated with rabeprazole sodium enteric coated tablets combined with clarithromycin and amoxicillin.We compared the efficacy of the two groups.Results:In the observation group,the rate of abdominal pain relief and the total effective rate of treatment were significantly higher than those in the control group;the time of abdominal pain relief was significantly shorter than that in the control group;the incidence and recurrence rate of adverse reactions were significantly lower than those in the control group;the differences were statistically significant(P<0.05).Conclusion:The efficacy of rabeprazole combined with clarithromycin and amoxicillin in the treatment of benign gastric ulcer was significant.It can effectively inhibit HP and improve the relieving effect of abdominal pain,with less adverse reactions and low recurrence rate.