血浆D-二聚体及血清同型半胱氨酸检测在肝脏疾病诊断中的应用价值

The application value of plasma D-dimer and serum homocysteine detection in the diagnosis of liver diseases

目的:探讨血浆D-二聚体及血清同型半胱氨酸(Hcy)水平在不同时期肝脏疾病中的变化及诊断价值。方法:2018年1月-2019年4月收治不同时期肝病患者152例,其中慢性乙型肝炎55例,肝炎后肝硬化52例,肝癌45例。另选择健康体检者50例作为正常对照组。采用免疫比浊法、循环酶法对不同时期肝病患者及正常对照组进行血浆D-二聚体及血清Hcy的检测并进行比较。结果:慢性乙型肝炎、肝硬化及肝癌患者血浆D-二聚体及血清Hcy水平均高于正常对照组,差异有统计学意义(P<0.05);且随病情严重程度的增加而增加。结论:血浆D-二聚体及血清同Hcy水平随肝脏疾病严重程度而增高,故其检测可以作为肝脏病变的监测指标,在疾病的诊断和预后、病情评估方面具有一定价值。

Objective:To explore the changes and diagnostic value of plasma D-dimer and serum homocysteine(Hcy)levels in different stages of liver diseases.Methods:152 patients with liver diseases in different periods were selected from January 2018 to April 2019,including 55 cases of chronic hepatitis B,52 cases of liver cirrhosis and 45 cases of liver cancer,and 50 healthy people were selected as the normal control group.The serum D-dimer and Hcy were detected by immunoturbidimetry and circulating enzyme method in patients with liver disease at different stages and normal control group.Results:The levels of D-dimer and Hcy in patients with chronic hepatitis B,liver cirrhosis and liver cancer were significantly higher than those in the control group,and the differences were statistically significant(P<0.05),which increase with the severity of the disease.Conclusion:The level of plasma D-dimer and serum homohcy increased with the severity of liver disease,so the detection of D-dimer can be used as a monitoring index of liver disease,which has a certain value in the diagnosis,prognosis and disease evaluation of the disease.