血清组织型纤溶酶原激活物-抑制剂复合物水平与冠心病的关联分析

The correlation analysis of the level of serum tissue plasminogen activator-plasminogen activator inhibitor-1 complex with risk of coronary heart disease

目的探讨血清组织型纤溶酶原激活物-抑制剂复合物(t⁃PAIC)水平与冠心病及冠状动脉病变程度之间的关系。方法选择2017年3月至2018年6月滁州市中西医结合医院155例经冠状动脉造影诊断为冠心病的病人,并选择同期在该院检查排除冠心病的对照人群160例。测量病人血清t⁃PAIC及其他常规生化指标含量。采用logistic回归模型分析血清t⁃PAIC水平与冠心病风险之间的独立关系,并使用多重线性回归分析冠心病病人冠脉病变程度的可能影响因素。结果在年龄、性别均衡可比的情况下,冠心病组病人血清t⁃PAIC水平为(12.97±4.47)ng/mL,高于对照组的(7.88±2.62)ng/mL(χ2=12.280,P<0.001)。logistic回归分析结果显示:血清t⁃PAIC水平较高的病人发生冠心病的OR值为1.49(1.25~1.79)。多元线性回归结果显示高血压、LDL⁃C、t⁃PAIC水平为冠心病病人冠脉狭窄程度的独立影响因素(P<0.05)。结论血清t⁃PAIC水平与冠心病发病风险之间存在正向关联,同时也与冠心病病人冠脉病变程度有关。

Objective To investigate the association of the level of serum tissue plasminogen activator⁃plasminogen activator inhibitor⁃1 complex(t⁃PAIC)with risks of coronary heart disease(CHD)and the degree of coronary artery lesions.Methods From March 2017 to June 2018,a total of 155 cases of CHD were recruited in our study.And 160 cases of controls were selected from these who were free of coronary heart disease in clinical laboratory of combine traditional Chinese and western medicine hospital.The serum t⁃PAIC and other conventional biochemical indexes were determined.The independent association between the serum t⁃PAIC and risk of CHD was analyzed by logistic regression,and the possible influencing factors of the degree of coronary artery lesions were ana⁃lyzed by multiple linear regression.Results There was no significant difference in characteristics of age and gender between CHD and control group.The level of serum t⁃PAIC in the CHD group was(12.97±4.47)ng/mL,which was significantly higher than that in the control group(7.88±2.62)ng/mL(χ2=12.280,P<0.001).The binary logistic regression analysis indicated that the OR of the risk of CHD was 1.49(1.25⁃1.79)for patients with higher level of serum t⁃PAIC.The results of multiple linear regression analysis show that the high blood pressure,LDL⁃C,serum t⁃PAIC level were the independence influencing factors for the degree of coronary artery lesions(P<0.05).Conclusion The levels of serum t⁃PAIC was associated with CHD as well as the degree of coronary artery lesions.