针刺对重型颅脑损伤昏迷促醒作用的系统评价

Systematic review of acupuncture on waking comatose patients after severe craniocerebral injury

目的系统评价针刺治疗重型颅脑损伤后昏迷的有效性及安全性,为今后研究策略提供依据。方法采用计算机进行文献检索中国知网、维普、万方、中国生物医学文献数据库。检索主题词为电针、针刺、促醒、重型颅脑损伤、昏迷、植物状态等,对符合标准的随机对照试验或半随机对照试验依据循证医学的原则和方法进行系统评价。结果共纳入9篇文献,455例患者。Meta分析结果显示,试验组与对照组比较,其总有效率、基本痊愈率、促醒率、格拉斯哥昏迷量表(GCS)评分差异均有统计学意义。结论针刺治疗重型颅脑损伤后昏迷有一定的疗效优势,但所纳入研究文献质量不髙,其有效性及安全性仍有待髙质量的临床试验进一步验证。

Objective To evaluate the effects and safety of acupuncture therapy treating comatose patients after severe craniocerebral injury,providing the basis for future research strategies.Methods Randomized controlled trials(RCT)and quasi-randomized controlled trials(q-RCT)which meet the standards were searched by computerized methods,and analysis and evaluation of literature were based on the principles and methods of evidence based medicine.Results Nine papers and 455 patients were identified.Meta-analysis showed that acupuncture group was better than control group in terms of total effective rate,basic curative rate,awakening rate,GCS scores.Conclusion Acupuncture therapy treating comatose patients after severe craniocerebral injury is effective.However,the quality of relevant trials is relatively low.Therefore,more RCTs of higher quality are needed to further confirm its effects and safety.