大剂量奥曲肽分别联合兰索拉唑、奥美拉唑治疗肝硬化并上消化道出血的效果比较

Comparison of the effects of high-dose octreotide combined with lansoprazole and omeprazole in the treatment of cirrhosis with upper gastrointestinal bleeding

目的比较大剂量奥曲肽分别联合兰索拉唑、奥美拉唑治疗肝硬化并上消化道出血的效果。方法回顾性分析我院收治的157例肝硬化并上消化道出血患者的临床资料,其中采用大剂量奥曲肽联合兰索拉唑治疗者79例,设为A组;采用大剂量奥曲肽联合奥美拉唑治疗者78例,设为B组。比较两组的治疗效果。结果治疗后3 d,两组的胃液pH及血红蛋白水平均升高,且A组高于B组(P<0.05)。A组的止血时间短于B组(P<0.05)。A组的治疗总有效率高于B组(P<0.05)。结论大剂量奥曲肽联合兰索拉唑治疗肝硬化并上消化道出血,更利于改善患者的胃液pH和血红蛋白水平,缩短出血时间,提高治疗效果。

Objective To compare the effects of high-dose octreotide combined with lansoprazole and omeprazole in the treatment of cirrhosis with upper gastrointestinal bleeding.Methods The clinical data of 157 cirrhosis patients with upper gastrointestinal bleeding admitted in our hospital were analyzed retrospectively.Among them,79 cases were treated with high-dose octreotide combined with lansoprazole,which was set as group A;78 cases were treated with high-dose octreotide combined with omeprazole,which was set as group B.The therapeutic effects of the two groups were compared.Results Three days after treatment,the gastric juice pH and hemoglobin level in both groups increased,and those in the group A were higher than the group B(P<0.05).The hemostasis time in the group A was shorter than that in the group B(P<0.05).The total effective rate of treatment in the group A was higher than that in the group B(P<0.05).Conclusion High-dose octreotide combined with lansoprazole in the treatment of cirrhosis with upper gastrointestinal bleeding is more conducive to ameliorate the gastric juice pH and hemoglobin level,shorten the hemostasis time and improve the treatment effect of patients.