克罗恩病患者的凝血指标变化情况研究

Study on the changes of coagulation indexes in patients with Crohn’s disease

目的研究克罗恩病(CD)患者的凝血指标变化情况。方法回顾性分析2015年1月至2019年6月首次诊断的53例CD患者(CD组)和54例健康志愿者(健康对照组)的临床资料。比较两组受检者的凝血指标、CD组不同活动度患者的凝血指标,分析凝血指标与克罗恩病疾病活动指数(CDAI)评分的相关性。结果CD组患者的纤维蛋白原水平、血小板计数、APTT均高于健康对照组(P<0.05);缓解期患者的纤维蛋白原、FDP水平、PT及APTT均显著低于中度活动期患者(P<0.05);Pearson线性相关性分析结果显示,纤维蛋白原、血小板计数、FDP及PT与CDAI呈正相关(P<0.05)。结论CD患者的凝血指标较正常人均显著升高,且纤维蛋白原、血小板计数、FDP及PT及和克罗恩病疾病的活动度密切相关。

Objective To study the changes of coagulation indexes in patients with Crohn's disease(CD).Methods The clinical data of 53 CD patients who diagnosed for the first time(CD group)and 54 healthy volunteers(healthy control group)from January 2015 to June 2019 were analyzed retrospectively.The coagulation indexes of the two groups and those of patients with different activity in the CD group were compared,the correlation between coagulation indexes and Crohn's disease activity index(CDAI)scores of Crohn's disease were analyzed.Results The levels of fibrinogen,platelet count and APTT in the CD group were significantly higher than those in the healthy control group(P<0.05).The levels of fibrinogen,FDP,PT and APTT in patients with remission stage were significantly lower than those in patients with moderate activity stage(P<0.05).Pearson linear correlation analysis showed that fibrinogen,platelet count,FDP and PT were positively correlated with CDAI(P<0.05).Conclusion The coagulation indexes of CD patients are significantly higher than those of normal people,and fibrinogen,platelet count,FDP and PT are closely related to the activity of Crohn's disease.