沙丁胺醇联合布地奈德雾化吸入对哮喘患儿EOS计数、IgE水平及肺功能的影响

Effects of salbutamol combined with budesonide aerosol inhalation on EOS count,IgE level and pulmonary function in children with asthma

目的探讨沙丁胺醇联合布地奈德雾化吸入对哮喘患儿嗜酸性粒细胞(EOS)计数、免疫球蛋白E(IgE)水平及肺功能的影响。方法选择2017年1月至2018年12月我院收治的哮喘患儿94例,按随机数表法将其分为观察组与对照组,各47例。对照组给予布地奈德雾化吸入,观察组在此基础上给予沙丁胺醇雾化吸入。比较两组治疗前、后EOS计数、IgE水平及肺功能指标。结果治疗后,两组EOS计数、IgE水平均降低,且观察组低于对照组(P<0.05)。治疗后,两组的FEV1、FEV1/FVC、PEF均升高,且观察组高于对照组(P<0.05)。结论沙丁胺醇联合布地奈德雾化吸入治疗小儿哮喘能够显著降低患儿EOS计数、IgE水平,改善肺功能,值得临床推广。

Objective To investigate the effect of salbutamol combined with budesonide aerosol inhalation on eosinophile granulocyte(EOS)count,immunoglobulin E(IgE)level and pulmonary function in children with asthma.Methods Ninety-four children with asthma admitted to our hospital from January 2017 to December 2018 were selected and divided into observation group and control group by the random number table method,with 47 cases in each group.The control group was given budesonide inhalation,and the observation group was given salbutamol inhalation on this basis.The EOS counts,IgE levels and pulmonary function indexes before and after treatment in the two groups were compared.Results After treatment,the EOS counts and IgE levels of the two groups decreased,and those in the observation group were lower than the control group(P<0.05).After treatment,FEV1,FEV1/FVC and PEF of the two groups increased,and those in the observation group were higher than the control group(P<0.05).Conclusion Salbutamol combined with budesonide aerosol inhalation can significantly reduce the EOS count,IgE level and improve pulmonary function in children with asthma,which is worthy of clinical promotion.