长链非编码RNAs调控骨稳态研究进展

Research progress in the regulation of bone homeostasis by long noncoding RNAs

骨形成和骨吸收是骨稳态维持的两个重要过程,骨稳态失衡可导致多种骨代谢疾病的发生。长链非编码RNAs(lncRNAs)是一类几乎不具有编码功能的RNAs,在调节基因表达、生命发育及疾病发生发展中起重要调控作用。在骨代谢疾病中多种lncRNAs表达异常,lncRNAs通过调节成软骨分化、成骨分化和骨基质矿化过程,调控骨的形成。并通过影响破骨细胞的分化和成熟,参与骨吸收过程的调节。

Bone formation and bone resorption are two important processes of bone homeostasis maintenance, and the imbalance of bone homeostasis can lead to a variety of bone metabolic diseases. Long noncoding RNAs(lncRNAs) are a subset of RNAs with only rarely encoding proteins and play important regulatory role in regulation of gene expression, life development and disease occurrence.In bone metabolic diseases, lots of lncRNAs are abnormally expressed. LncRNAs regulate bone formation process through regulating chondrogenic differentiation, osteogenic differentiation and bonematrix mineralization. By affecting the differentiation and maturation of osteoclasts,lncRNAs are involved in the regulation of bone resorption.