苯基丙氨酸修饰石墨烯平面电极对西酞普兰的灵敏检测

Sensitive Detection of Citalopram by a Phenylalanine Modified Graphene Platform Electrode

通过高分子支撑法,将化学气相沉积(CVD)法得到的石墨烯从铜基底转移到聚对苯二甲酸乙二醇(PET)基底上,制备出柔性石墨烯平面电极(GPE),再通过循环伏安法将苯基丙氨酸(PHE)沉积到GPE上,得到了苯基丙氨酸修饰的石墨烯平面电极(PHE/GPE)。研究表明,治疗抑郁症的药物西酞普兰(CIT)在PHE/GPE上有明显的氧化峰出现,从而构建一种新型CIT传感器。该传感器在CIT浓度为0.5~88μmol/L范围内,其响应电流与浓度分段呈现良好的线性关系,检出限(S/N=3)为0.044μmol/L。该CIT传感器具有制备过程简单、成本低,对CIT响应灵敏、检出限低等优点。

The chemical vapor deposition grown graphene was transferred onto polyethylene terephthalate surface by polymer support method to fabricate a graphene planar electrode(GPE).Then phenylalanine(PHE) was electrodeposited on the GPE to form a phenylalanine modified GPE(PHE/GPE).It was found that the depressive disorder curing medicine citalopram(CIT) displayed a well-defined oxidation peak with highly enhanced peak currents.Thus a new type of CIT sensor was established.The PHE/GPE sensor presented a linear range from 0.5 μmol/L to 88 μmol/L with a detection limit of 0.044 μmol/L(S/N=3).In addition,the proposed sensor was easy to fabricate with low cost and showed excellent stability and anti-interference ability.