孕期饮茶与早产、流产风险关联的Meta分析

Association of tea drinking during pregnancy and preterm delivery or abortion: A meta-analysis

目的系统评价孕产妇孕期饮茶与早产、流产风险的关联。方法系统检索中国知网、万方中国学术期刊数据库、维普中文科技期刊数据库、中国生物医学文献数据库、PubMed和Web of Science等中英文数据库,收集建库至2019年6月30日有关孕期饮茶与早产、流产风险关联的队列研究和病例对照研究文献,采用相对危险度(RR)或优势比(OR)作为效应指标进行Meta分析。结果初期共检索文献1099篇,最终纳入文献14篇,其中队列研究9篇,包括暴露组18295例,非暴露组71890例;病例对照研究5篇,包括病例组1351例,对照组3059例。Meta回归分析结果显示,孕期饮茶与早产、流产风险无统计学关联(OR/RR=1.08,95%CI:0.99~1.18)。随机效应线性回归分析结果显示,随着孕期饮茶量增加,孕产妇早产、流产风险未发生明显变化(OR/RR=1.05,95%CI:0.99~1.11)。Begg’s检验和Egger’s检验均未发现发表偏倚。结论孕期饮茶与早产、流产风险未见统计学关联。

Objective To analyze the association between tea drinking during pregnancy and the risk of preterm delivery and abortion, so as to provide basis for prevention of preterm delivery and abortion. Methods The databases of CNKI, Wanfang,VIP,CBMdisc,PubMed and Web of Science were searched for cohort studies and case-control studies into the association between tea consumption during pregnancy and preterm delivery or abortion until June 30 th,2019. Relative risk(RR) or odds ratio(OR)were used as indicators for the meta-analysis. Results A total of 1 099 articles were retrieved, 14 of them were included in the quantitative study,including 9 cohort studies with 18 295 exposed and 71 890 unexposed individuals and 5 case-control studies with 1 351 cases and 3 059 controls. There was no statistically significant association between tea drinking during pregnancy and pretermbirth or abortion(OR/RR=1.08,95%CI:0.99-1.18). The linear regression model ofrandomeffect showed that with the increase of tea consumption during pregnancy, the risk of premature delivery and abortion did not change significantly(OR/RR=1.05,95%CI:0.99-1.11). There was no publication bias found in Begg’s test and Egger’s test. Conclusion Drinking tea during pregnancy is not associated with preterm delivery and abortion.