头孢哌酮钠/舒巴坦钠静脉输注致凝血功能障碍1例

A case of coagulation disorders induced by cefoperazone sodium and sulbactam sodium for injection

1例78岁男性患者,因肺部感染入院,临床诊断为肺部感染、冠状动脉粥样硬化性心脏病、心力衰竭,给予头孢哌酮钠/舒巴坦钠(3.0 g,q 8 h,ivgtt)抗感治疗。治疗第6天患者出现凝血功能异常,凝血酶原时间(PT)61.6 s,凝血酶原活动度(PTA)6%,国际标准化比值(INR)5.44,活化部分凝血活酶时间(APTT)30.7 s。考虑凝血功能障碍为头孢哌酮钠/舒巴坦钠所致,立即停药。给予输注新鲜冰冻血浆,肌注维生素K1。治疗第12天,患者复查凝血功能,PTA 56%,PT 16.3 s,INR 1.4,APTT 27.2 s,停药7 d后不良反应未再发生,凝血功能无异常。

A 78-year-old male patient was hospitalized mainly because of pulmonary infection.The patient was diagnosed as pulmonary infection,coronary atherosclerotic heart disease and heart failure.Cefoperazone sodium and sulbactam sodium(3.0 g,q 8 h,ivgtt)was given to the patient.Six days later,the patient developed coagulation disorders.Laboratory tests showed that the prothrombin time(PT)was 61.6 s,the prothrombin activity(PTA)was 6%,the international normalized ratio(INR)was 5.44 and the activated partial thromboplastin time(APTT)was 30.7 s.Coagulation disorders induced by cefoperazone sodium/sulbactam sodium was considered and cefoperazone sodium/sulbactam sodium was stopped immediately,and fresh frozen plasma and vitamin K1 were given to the patient immediately.On the 12 th day,results of blood coagulation tests showed that PTA was 56%,PT was 16.3 s,INR was 1.4,APTT was 27.2 s.The coagulation function recovered to normal status 7 days after withdrawal.