日本血吸虫虫卵肉芽肿免疫病理机制研究进展

Research progress on the immunopathological mechanism of Schistosoma japonicum egg-induced granuloma

宿主感染日本血吸虫后,虫卵可沉积于宿主的肝脏和肠壁等组织,引起Th2型为主的免疫应答,导致虫卵肉芽肿的形成和纤维化。该过程涉及多种类型的细胞参与,如中性粒细胞、巨噬细胞、嗜酸粒细胞、自然杀伤细胞、B细胞(包括调节性B细胞)、T细胞[包括辅助性T细胞(Th)1、2和17等细胞亚型]、调节性T细胞、肝星状细胞和肝细胞等。本文综述了参与日本血吸虫虫卵肉芽肿免疫反应的细胞类型及其可能的作用机制,以期为相关工作者提供参考。

After infection with Schistosoma japonicum,mature female adult worms lay eggs which deposit in the liver,intestinal wall,and other tissues of the infected mammalian host,which induces predominant Th2 immune responses and causes egg granuloma and fibrosis.It has been reported that neutrophils,macrophages,eosinophils,natural killer cells,B cells(including regulatory B cells),T cells(including Th1,Th2,and Th17 cells),Treg cells,hepatic stellate cells,and hepatocytes are involved in this process.In this paper,we reviewed the cell types involved in the egg granulomatous response of S.japonicum and their possible mechanisms in order to provide a helpful reference for related researchers in this field.