氯吡格雷在儿科中的应用进展

Application of clopidogrel in pediatric care

氯吡格雷作为新型的抗血小板药物,在儿科的用药需求日趋增多,氯吡格雷在药动学、药效学以及降低某些不良反应的发生方面较其他抗血小板药物具有优势,本文拟综述氯吡格雷机制、药理学,以及在儿科使用情况,主要包括儿科应用的疾病种类和剂量选择等,并初步探讨了基因检测对儿童氯吡格雷的指导价值,为儿科临床合理应用氯吡格雷提供依据。

Clopidogrel,a novel and effective antiplatelet drug,is in increasing demand in pediatric care.Clopidogrel has advantages over other antiplatelet drugs in pharmacokinetics,pharmacodynamics,and reduction of certain adverse effects,but it is still at the exploratory stage for pediatric applications.This article intends to review the mechanism,pharmacology and pediatric use of clopidogrel,mainly including the types of diseases used in pediatrics and dose selection,and preliminarily explore the guiding value of genetic testing for clopidogrel in children,providing the basis for the rational use of clopidogrel in pediatrics.