HIV感染基因治疗新思路

New thought for gene therapy against HIV infection

获得性免疫缺陷综合征,即AIDS是由HIV感染引起的一种严重危害人类健康的全球性传染病。目前随着抗病毒疗法的应用,HIV复制得到有效阻断,AIDS成为一种慢性可控的疾病,但该治疗方式无法彻底清除HIV,因此AIDS无法得到根治。随着对HIV感染机制研究的不断深入以及基因治疗技术的迅猛发展,诸如RNA沉默、DNA编辑等基因疗法为根治AIDS提供一种新的思路,上述这些新技术具有抑制或彻底清除宿主体内HIV的可能,且可以避免传统治疗手段带来的不良反应。本研究就这些相关基因治疗在应对HIV感染方面的最新研究进展加以总结和探讨。

Acquired immunodeficiency syndrome(AIDS)is a global epidemic infectious disease caused by HIV infection,which is severely harmful to human health.With the application of antiretroviral therapy,HIV replication has been effectively suppressed.AIDS becomes chronic and manageable,but this therapy fails to eliminate viruses.Therefore,there is no radical solution to AIDS.With a deeper understanding of the mechanism of HIV infection and the advanced development of gene therapy technology,gene therapy such as RNA silencing and DNA editing provides novel approaches for radical treatment of AIDS.These new technologies may inhibit or eradicate thoroughly HIV and avoid adverse effects caused by conventional therapies.In this paper,the advanced progress in gene therapy against HIV infection is summarized and explored.