急性脑梗死患者血清缺血修饰蛋白表达水平与神经功能缺损程度及预后的关系

The relationship between expression level of serum ischemia-modified albumin and neurological deficit and prognosis in patients with acute cerebral infarction

目的探讨急性脑梗死患者血清缺血修饰蛋白(Ischemia-modified albumin,IMA)表达水平与神经功能缺损程度及预后的关系。方法选择2016年1月~2017年12月在本院神经内科住院的急性脑梗死患者84例作为脑梗死组,同期选择本院健康体检的健康人群80例作为对照组,用美国国立卫生研究院卒中量表(NIHSS)对神经功能缺损程度进行评分,用Modified Rankin量表(MRS)进行预后评价,检测血清中IMA水平,分析其与脑梗死患者预后的关系。结果与对照组比较,脑梗死组血清中IMA水平增高(P<0.05);随着神经功能缺损程度的加重,脑梗死患者血清中IMA水平增高,预后不良脑梗死患者血清中IMA水平高于预后良好患者(P<0.05);用四分位数法将脑梗死患者血清IMA水平从低到高分组显示,随IMA水平的增加,脑梗死患者预后不良率逐渐增高,脑梗死患者预后不良的风险也增加(P<0.05)。结论急性脑梗死患者血清中IMA水平显著升高,其水平与神经功能缺损程度及预后密切相关。

Objective To investigate the relationship between expression level of serum ischemia-modified albumin(IMA) and neurological deficit and prognosis in patients with acute cerebral infarction. Methods 84 cases of acute cerebral infarction(infarction group) treated in the neurology department and 80 cases of health examineers(control group) in the medical examination center of our hospital from January 2016 to December 2017 were selected and were assessed by various scales, including national institutes of health stroke scale(NIHSS) and modified Rankin Scale(mRS). Then serum IMA levels in two groups were tested, the correlation between serum IMA levels and neurological deficit, prognosis was analyzed. Results The serum IMA levels of the infraction group were higher than those of the control group(P<0.05). Within the infraction group, the serum IMA levels were increased with the neurological deficit degree. Moreover, the serum IMA level of patients with poor prognosis was higher than that of patients with good prognosis(P<0.05). Patients in the fraction group were ranked in a descending order according to the IMA levels, which showed that the poor prognosis rate and risk were increased with the IMA levels(P<0.05). Conclusion The serum level of IMA in patients with acute cerebral infarction was significantly elevated, which was closely related to the neurological deficit degree and prognosis.