LncRNAs在甲状腺癌中的生物学功能及其临床价值研究进展

Progress in Biological Functions and Clinical Significance of Long NonCoding RNAs in Thyroid Cancer

甲状腺癌是最常见的内分泌系统恶性肿瘤之一,近几十年来发病率增加迅速。虽然大多数甲状腺癌预后良好,但有些病例仍可能会分化成更具侵袭性和致命性的甲状腺癌。越来越多的证据表明lncRNAs在人类癌症发生发展中发挥作用,但其在甲状腺癌中的具体作用和机制仍很不明确。在本综述中,我们总结了近年来与甲状腺癌相关的lncRNAs的新发现,并讨论其作为甲状腺癌诊断、预后生物标志物和治疗靶点的潜在价值。

Thyroid cancer is one of the most common endocrine cancers with rapidly increasing incidence in recent decades.Although the majority of patients with thyroid cancer have a good prognosis,there is still a risk that some cases may develop into more aggressive and lethal thyroid cancers.Long noncoding RNAs(lncRNAs)have recently been demonstrated to participate in cancer progression.However,their role and molecular mechanism in thyroid cancer remain unclear.In this review,we summarize the latest findings regarding the functions and mechanism of lncRNAs in thyroid cancer,and discuss their potential clinical significance in diagnosis,prognostic biomarkers and therapeutic targets of thyroid cancer.