不同剂量甲泼尼龙琥珀酸钠治疗小儿重症支原体肺炎的临床价值研究

Clinical value of different doses of sodium methoprene succinate in the treatment of severe Mycoplasma pneumonia in children

目的不同剂量甲泼尼龙琥珀酸钠治疗小儿重症支原体肺炎患者的效果分析。方法选取2016年1月至2018年10月本院收治的小儿重症支原体肺炎患者200例,随机分为观察组和对照组,各100例。按照对比用药的方式展开治疗,对照组主要以低剂量甲泼尼龙琥珀酸钠治疗;观察组主要以大剂量甲泼尼龙琥珀酸钠治疗,对两组治疗效果进行分析。结果观察组总有效率为97.00%(97/100),远高于对照组的84.00%(84/100),比较差异有统计学意义(P<0.05)。两组退热时间、啰音消失时间、咳嗽消失时间以及住院时间比较,观察组均存在显著优势,差异有统计学意义(P<0.05)。观察组有2例患者出现不良反应,对照组有7例患者出现不良反应,观察组不良反应发生率明显较低,差异有统计学意义(P<0.05)。结论对小儿重症支原体肺炎患者按照大剂量甲泼尼龙琥珀酸钠治疗,可进一步提升临床对该类患者的治疗效果,迅速改善患儿各方面症状,加快恢复速度,该用药方案值得在临床推广应用。

Objective To analyze the effect of different doses of sodium methanilonsuccinate in children with severe Mycoplasma pneumonia.Methods From January 2016 to October 2018, 200 patients were selected and treated according to the way of comparative medication, and they were divided into the control group and the observation group, with 100 cases in each group. The control group were mainly treated with low dose of methylprednisolone sodium succinate, and the observation group were mainly treated with high dose of methylprednisolone sodium succinate. The difference between the two groups were analyzed. Results The overall effective rate of the observation group was 97.00%(97/100), which was much higher than that of the control group 84.00%(84/100). The comparison showed that the observation group had significant difference(P<0.05).In combination with the statistics of the two groups, the time of deheating, the time of disappearance of the sound, the time of cough disappearance,and the time of hospitalization, there were significant difference in the two groups(P<0.05). In the treatment, a total of 2 patients in the observation group had adverse reactions, while 7 patients in the control group had adverse reactions. The comparison showed that the incidence rate of the observation group was significantly lower(P<0.05). Conclusion The treatment of children with severe Mycoplasma pneumonia with high dose of sodium methoprene succinate can further improve the effect of clinical treatment of this type of patients, help the children’ s symptoms to be quickly improved, and accelerate the recovery rate, it is worth using the drug plan in clinical practice.