期刊文献+

西达本胺治疗难治性结外NK/T细胞淋巴瘤的临床有效率分析 被引量:1

Clinical efficacy of cidabenamine in the treatment of refractory extranodal NK/T-cell lymphoma
下载PDF
导出
摘要 目的探讨西达本胺治疗难治性结外NK/T细胞淋巴瘤的临床有效率分析。方法选择2015年1月至2017年12月收治的40例难治性结外NK/T细胞淋巴瘤患者作为研究对象,按照随机数字表法分为对照组与研究组,各20例。对照组仅接受常规化疗治疗,研究组则接受常规化疗联合西达本胺治疗,比较分析两组临床治疗效果、不良反应。结果研究组的治疗总有效率为85.00%,显著高于对照组的55.00%,组间差异有统计学意义(x^2=4.285 7,P=0.038 4);研究组的不良反应发生率为15.00%,与对照组20.00%比较,组间差异无统计学意义(x^2=0.173 2,P=0.677 3)。结论难治性结外NK/T细胞淋巴瘤应用西达本胺治疗的临床有效率确切,且不良反应发生率低,治疗安全性高。
作者 张敏
出处 《当代医学》 2020年第3期116-117,共2页 Contemporary Medicine
  • 相关文献

参考文献10

二级参考文献54

  • 1Zhang C, Richon V, Ni X, et al. Selective induction of apoptosis by histone deacetylase inhibitor SAHA in cutaneous T-cell lymphoma cells: relevance to mechanism of therapeutic action [J]. J Invest Dermatol, 2005, 125 (5): 1045-1052. DOI: 10.1111/j.0022-202X. 2005.23925.x.
  • 2Frescas D, Pagano M. Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer [J]. Nat Rev Cancer, 2008, 8 (6): 438-449. DOI: 10.1038/nrc2396.
  • 3Ning ZQ, Li ZB, Newman MJ, et al. Chidamide (CS055/HBI- 8000): a new histone deacetylase inhibitor of the benzamide class with antitumor activity and the ability to enhance immune cell- mediated tumor cell cytotoxicity [J]. Cancer Chemother Pharmacol, 2012: 69(4): 901-909. DOI: 10.1007/s00280-011-1766-x.
  • 4Zhang C, Li B, Zhang X, et al. Curcumin selectively induces apoptosis in cutaneous T-cell lymphoma cell lines and patients' PBMCs: potential role for STAT-3 and NF-kappaB signaling [J]. J Invest Dermatol, 2010, 130 (8): 2110-2119. DOI: 10.1038/jid. 2010.86.
  • 5Dong M, Ning ZQ, Xing PY,et al. Phase I study of chidamide (CS055/HBI-8000), a new histone deacetylase inhibitor, in patients with advanced solid tumors and lymphomas [J]. Cancer Chemother Pharmacol, 2012, 69 (6): 1413-1422. DOI: 10.1007/ s00280-012-1847-5.
  • 6Duvic M, Vu J. Update on the treatment of cutaneous T-cell lymphoma ( CTCL ): Focus on vorinostat [J]. Biologics, 2007, 1 ( 4 ): 377-392.
  • 7Duvic M, Talpur R, Ni X, et al. Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL)[J]. Blood, 2007, 109 (1): 31-39. DOI: 10.1182/blood-2006-06-025999.
  • 8Piekarz RL, Frye R, Turner M, et al. Phase II multi-institutional trial of the histone deacetylase inhibitor romidepsin as monotherapy for patients with cutaneous T-cell lymphoma [J]. J Clin Oncol, 2009, 27(32): 5410-5417. DOI: 10.1200/JCO.2008.21.6150.
  • 9Qiao Z, Ren S, Li W, et al. Chidamide, a novel histone deaeetylase inhibitor, synergistically enhances gemcitabine eytotoxieity in pancreatic cancer cells [J]. Biochem Biophys Res Commun, 2013, 434( 1 ): 95-101. DOI: 10.1016/j.bbrc.2013.03.059.
  • 10Dang M, Ning ZQ, Xing PY, et al. Phase I study of chidamide (CS055/HBI-8000), a new histone deaeetylase inhibitor, in patients with advanced solid tumors and lymphomas [J]. Cancer Chemother Pharmaeol, 2012, 69 (6): 1413-1422. DOI: 10.1007/s00280-012-1847 -5.

共引文献46

同被引文献11

引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部