血清外泌体RNA-122在丙肝病毒感染者中的表达水平

Expression Level of Serum Exosomal RNA-122 in Patients Infected With Hepatitis C Virus

目的探讨丙型肝炎病毒感染患者血清中RNA-122的表达及其在临床中的意义。方法择取我院收治的31例丙肝病毒感染患者,选择时间段为2017年7月—2018年12月,纳入丙肝组,择取同期的健康者31例纳入健康组,所有研究对象均接受血清外泌体RNA测定,对比两组患者的RNA-122表达水平。结果以健康者的RNA122表达水平为标准,设定为1.00,丙肝组患者的RNA-122表达水平(1.36±0.15)高于健康组的表达水平(1.00±0.00),组间数据对比差异有统计学意义(P<0.05)。结论针对丙肝患者给予血清外泌体的RNA-122测定,其表达水平高于健康者表达水平且具有显著差异,RNA-122可作为检测丙型肝炎感染的一种生物学标志物,具有重要的临床意义。

Objective To investigate the expression of RNA-122 in serum of patients with hepatitis C virus infection and its clinical significance.Methods Thirty-one patients with hepatitis C virus infection were enrolled in our hospital.The time period was from July 2017 to December 2018.The patients were enrolled in the hepatitis C group.31 healthy subjects were enrolled in the healthy group.All subjects accepted Serum exosomal RNA was measured and the RNA-122 expression levels were compared between the two groups.Results The expression level of RNA122 in healthy subjects was set to 1.00,and the expression level of RNA-122 in patients with hepatitis C was(1.36±0.15)higher than that in healthy group(1.00±0.00).There is a significant advantage in the comparison of data between groups.There is statistical reference value(P<0.05).Conclusion The RNA-122 assay for serum exosomes in patients with hepatitis C is significantly higher than that of healthy individuals.RNA-122 can be used as a biomarker for detecting hepatitis C infection.