β2-肾上腺素受体激动剂联合糖皮质激素治疗老年支气管哮喘急性期的临床效果

Clinical Effect of β2-adrenergic Receptor Agonist Combined with Glucocorticoids in the Treatment of Acute Stage of Elderly Bronchial Asthma

目的:探讨β2-肾上腺素受体激动剂联合糖皮质激素治疗老年支气管哮喘急性期患者的临床效果。方法:回顾性分析2018年1-12月于笔者所在医院接受治疗的176例老年支气管哮喘急性期患者的临床资料,根据不同的治疗方法分为对照组与观察组,各88例。对照组使用糖皮质激素治疗,观察组在对照组基础上使用β2-肾上腺素受体激动剂治疗,对比两组肺功能指标和症状改善时间等。结果:观察组总有效率高于对照组(P<0.05);两组治疗前环磷酸腺苷(cAMP)对比,差异无统计学意义(P>0.05);两组治疗1、2周后cAMP水平均高于治疗前,差异均有统计学意义(P<0.05);观察组治疗1、2周后cAMP水平均高于对照组,差异均有统计学意义(P<0.05);观察组治疗后肺功能改善情况优于对照组,差异有统计学意义(P<0.05);观察组咳嗽、喘息、肺哮鸣音和肺啰音改善时间均早于对照组(P<0.05)。结论:在老年支气管哮喘急性期患者治疗过程中使用β2-肾上腺素受体激动剂联合糖皮质激素,能够改善cAMP和肺功能水平,缩短咳嗽、喘息、肺哮鸣音与肺啰音改善时间,提高治疗总有效率,值得临床推广使用。

Objective:To investigate the clinical effect ofβ2-adrenergic Receptor Agonist combined with Glucocorticoids in the treatment of acute stage of elderly bronchial asthma.Method:The clinical data of 176 patients with acute stage of elderly bronchial asthma treated in our hospital from January to December 2018 were analyzed retrospectively.According to different treatment methods,all patients were divided into the control group and the observation group,88 cases in each group.The control group were treated with Glucocorticoid,and the observation group were treated withβ2-adrenergic Receptor Agonist on the basis of the control group.The pulmonary function indexes and the symptoms improvement time were compared between the two groups.Result:The total effective rate of the observation group was higher than that of the control group(P<0.05).And before treatment,cyclic adenosine monophosphate(cAMP)were compared between the two groups,and the difference was not statistically significant(P>0.05).After 1 and 2 weeks of treatment,the levels of cAMP in the two groups were significantly higher than those before treatment,and the differences were statistically significant(P<0.05).After 1 and 2 weeks of treatment,the levels of cAMP in the observation group were significantly higher than those of the control group,and the differences were statistically significant(P<0.05).After treatment,the improvement of pulmonary function in the observation group were significantly better than those of the control group,and the differences were statistically significant(P<0.05).The improvement time of cough,wheezing,wheezing sound and rales in the observation group were significantly earlier than those of the control group(P<0.05).Conclusion:Usingβ2-adrenergic Receptor Agonist combined with Glucocorticoids in the treatment of acute stage of elderly bronchial asthmacan improve the level of cAMP and pulmonary function,shorten the improvement time cough,wheezing,wheezing sound and rales,and improve the total effective rate of treatment,it is worth popularizing and using in clinic.