头花千金藤碱逆转肿瘤多药耐药作用机制研究进展

Research progress on reversion of multidrug resistance in tumor by cepharanthine

综述头花千金藤碱在逆转肿瘤多药耐药方面的相关文献,归纳其对白血病、肝癌、卵巢癌、乳腺癌、食管癌、结肠癌等不同肿瘤的多药耐药逆转作用及机制,发现其逆转肿瘤多药耐药是一个多通路、多环节综合作用的结果,主要机制包括抑制膜转运蛋白功能、影响酶转移系统、抑制抗凋亡通路激活及抗凋亡蛋白表达。

This article reviews the related literature on the reversal of multi-drug resistance in tumors by cepharanthine,and summarizes the reversal effects and mechanisms of multi-drug resistance in different tumors such as leukemia,liver cancer,ovarian cancer,breast cancer,esophageal cancer and colon cancer.Its reversal effect on multi-drug resistance of tumors is the result of a multi-channel,multi-link combination.The main mechanism is to inhibit membrane transporter function,affect enzyme transfer system,inhibit anti-apoptotic pathway activation and anti-apoptotic protein expression.