吸入粉雾剂工程颗粒技术研究

Study on engineer particle technology of DPIs

对于吸入粉雾剂来说,由于活性药物成分(API)较小的粒径和较高的表面能,导致微粉易于团聚,难以分散。微粒间的内聚力和微粒与乳糖间的粘附力导致粉雾剂产品较低的微细粒子比例(FPF)。通过工程颗粒可以改善API微粒的物化性质,进而显著提高DPI产品的递送效率。概述通过工程颗粒的制备API微粉的方法,包括反溶剂结晶、湿法粉碎/研磨、喷雾/冷冻干燥、超临界流体等方法,可以显著提高粉雾剂的雾化性能。

Asaresult of small particlessize and highsur face energy,Active Pharmaceutical Ingredients of DPI stend to behighly agglomerated and poor dispersible. The DPIs exhibit low FPF due to the cohesion between fine particles and adhesion between fine particles and lactose.Through engineering particles, the physical and chemical properties of API particles can be improved, and the delivery efficiency of DPI products can be significantly improved. Methods of engineering particles were reviewed in the paper, involved antisolvent crystallized, wetmilling nano technology,spray/spray-freeze drying.These methods can significantly improveatomization performance of foggingagent.