磷酸肌酸钠联合果糖二磷酸钠治疗新生儿窒息后心肌损伤的疗效观察

Observation of creatine phosphate combined with fructose sodium diphosphate on myocardial injury after neonatal asphyxia

目的研究注射用磷酸肌酸钠联合果糖二磷酸钠注射液对新生儿窒息患儿心功能的影响。方法选择2015年1月-2018年6月宝鸡市人民医院收治的70例新生儿窒息后心肌损伤患儿作为研究对象,采用抽签法将患儿随机分为两组。对照组将果糖二磷酸钠注射液250 mg/(kg·d)溶于30 mL的10%葡萄糖溶液中静脉滴注。观察组在对照组治疗的基础上,将注射用磷酸肌酸钠0.5 g溶于30 mL的10%葡萄糖溶液中静脉滴注。两组均治疗2周。观察两组患者的临床疗效,同时比较两组治疗前后的肌酸激酶同工酶(CK-MB)、肌钙蛋白T(CTnT)、肌酸激酶(CK)和乳酸脱氢酶(LDH)水平及左室射血分数(LVEF)。结果治疗后,观察组的总有效率为94.29%,明显高于对照组的71.43%(P<0.05)。治疗后,两组CKMB、CTnT、CK和LDH水平均明显降低(P<0.05);且观察组血清学指标显著低于对照组(P<0.05)。治疗后,两组LVEF均明显升高(P<0.05),且观察组显著高于对照组(P<0.05)。结论注射用磷酸肌酸钠联合果糖二磷酸钠注射液可以提高新生儿窒息后心肌损伤的疗效,有效改善心功能,具有临床推广应用价值。

Objective To study the effect of Creatine Phosphate Sodium for Injection combined with Fructose Sodium Diphosphate Injection on cardiac function after neonatal asphyxia. Methods Selected 70 cases of patients with myocardial injury after neonatal asphyxia who were treated in Baoji People’s Hospital from January 2015 to June 2018, divided into two groups randomly. Children in the control group were injected with Fructose Sodium Diphosphate Injection, 250 mg/(kg·d) added into 10% glucose solution 30 mL. Children in the observation group were given intravenous infusion of Creatine Phosphate Sodium for Injection on the basis of control group, 0.5 g added into 10% glucose solution 30 mL. Children in two groups were treated for 2 weeks. After treatment, the clinical efficacy was evaluated, and the levels of CK-MB, CTnT, CK, LDH and LVEF in two groups before and after treatment were compared. Results After treatment, the effective rate of the observation group was 94.29%, which was significantly higher than71.43% in the control group(P < 0.05). After treatment, the serum CK-MB, CTnT, CK and LDH levels in two groups were significantly decreased(P < 0.05), and the serum indexes in the observation group were significantly lower than those in the control group(P < 0.05). After treatment, LVEF were increased significantly in two groups(P < 0.05), and the LVEF in the observation group were significantly higher than those in the control group(P < 0.05). Conclusion Creatine Phosphate Sodium for Injection combined with Fructose Sodium Diphosphate Injection can improve the efficacy of myocardial injury after neonatal asphyxia,effectively improve cardiac function, with clinical application value.