吗替麦考酚酯联合泼尼松治疗儿童肾病综合征的效果分析

Effect of mycophenolate mofetil combined with prednisone in treatment of children with nephrotic syndrome

目的探究吗替麦考酚酯分散片联合醋酸泼尼松片治疗儿童肾病综合征的效果。方法选择2016年1月-2018年1月于常州市儿童医院接受治疗的50例肾病综合征患儿作为研究对象,采用奇偶数法将患儿均分为两组,每组各25例。对照组接受环孢素软胶囊联合醋酸泼尼松片治疗,实验组接受替麦考酚酯分散片联合醋酸泼尼松片治疗,两组均持续治疗6个月。对比两组临床治疗总有效率、治疗中不良反应发生率及治疗前后IgA、IgG、IgM、蛋白排泄率(UAER)、血浆白蛋白(Alb)、尿素氮(BUN)、血肌酐(Scr)等指标变化。结果治疗后,实验组治疗总有效率显著高于对照组(P<0.05)。治疗后,两组IgA、IgG、IgM水平均高于治疗前,且实验组高于对照组(P<0.05),但对照组治疗后IgM水平与治疗前差异无统计学意义(P>0.05)。治疗后,两组UAER、BUN及Scr水平均显著降低,而Alb显著升高,且实验组改善更显著(P<0.05)。两组治疗期间药物不良反应发生率无显著差异(P>0.05)。结论吗替麦考酚酯分散片联合醋酸泼尼松片治疗儿童肾病综合征的效果良好,能够显著改善患儿免疫功能和肾功能,提高临床疗效,且治疗安全性较高。

Objective To investigate the effect of Mycophenolate Mofetil Tablets combined with Prednisone Acetate Tablets in treatment of children with nephrotic syndrome. Methods Children(50 cases) with nephrotic syndrome in Changzhou Children’s Hospital from January 2016 to January 2018 were divided into two groups according to odd and even number method, and each group had 25 cases. The control group were treated for Ciclosporin Soft Capsules combined with Prednisone Acetate Tablets. The experimental group were treated for Mycophenolate Mofetil Tablets combined with Prednisone Acetate Tablets. The two groups continued treatment for 6 months. Comparing the total effective rate of clinical treatment, the incidence of adverse reactions in the treatment, and IgA, IgG, IgM, UAER, Alb, BUN, Scr levels in two groups before and after treatment. Results The total effective rate of the experimental group was significantly higher than that of the control group(P < 0.05). After treatment, the levels of IgA, IgG and IgM in two groups were higher than those before treatment, and the experimental group was higher than the control group(P <0.05). However, there was no significant difference in the level of IgM between two groups after treatment(P > 0.05). After treatment, the levels of UAER, BUN and Scr were significantly decreased in two groups, while the levels of Alb were significantly increased, and the improvement in the experimental group was more significant(P < 0.05). There was no significant difference in the incidence of adverse drug reactions between the two groups(P > 0.05). Conclusion Mycophenolate Mofetil Tablets combined with Prednisone Acetate Tablets is effective in treatment of children with nephrotic syndrome, which can significantly improve the immune function and renal function of children, improve the clinical efficacy, and has higher treatment safety.