摘要
目的评价霍山石斛口服液食用的安全性。方法依据GB 15193.1-2014《食品安全国家标准食品安全性毒理学评价程序》,对霍山石斛口服液进行急性毒性实验、Ames实验、小鼠骨髓细胞微核实验、小鼠精子畸形实验、30 d喂养实验。结果小鼠对霍山石斛口服液最大耐受剂量(maximal tolerable dose,MTD)大于40 mL/kg BW,属无毒级;Ames实验显示小鼠骨髓细胞微核试验和小鼠精子畸形实验均检测为阴性;当霍山石斛口服液剂量达到10.0 mL/kg BW时,仍未见实验动物出现中毒体征。结论霍山石斛口服液无毒副作用,无遗传毒性,安全性高,可长期食用。
Objective To evaluate the safety of Dendrobium huoshanense oral solutionfor for consumption. Methods According to GB 15193.1-2014 Food safety national standard-Food safety toxicology evaluation procedure,acute toxicity test,Ames test,mouse bone marrow cell micronucleus test,mouse sperm abnormality test and 30 d feeding experiment were conducted on Dendrobium huoshanense oral solution. Results The maximum tolerable dose(MTD) of the mice to Dendrobium huoshanense oral solution was greater than 40 mL/kg BW,which was non-toxic. Ames experiments showed that mouse bone marrow cells micronucleus test and mouse sperm abnormality test were negative. When the oral dose of Dendrobium huoshanense oral solution reached 10.0 mL/kg BW,no poisoning signs were found in the experimental animals. Conclusion Dendrobium huoshanense oral solution has no toxic side effects,no genotoxicity,high safety and it is suitable for long-term consumption.
作者
马荣锋
王升贵
田小军
MA Rong-Feng;WANG Sheng-Gui;TIAN Xiao-Jun(Jiuxianzun Huoshan Dendrobium Huoshanense Co.,Ltd.,Shanghai 201199,China)
出处
《食品安全质量检测学报》
CAS
2019年第24期8462-8469,共8页
Journal of Food Safety and Quality
基金
安徽省重点研究和开发计划项目(1804a0802220)~~
关键词
霍山石斛口服液
可食用
安全性评价
Dendrobium huoshanense oral solution
edible
safety evaluation