郑启仲教授治疗儿童抽动障碍用药规律的数据挖掘研究

Data mining research on professor ZHENG Qizhong’s medicine law in the treatment of children with tic disorder

目的运用数据挖掘技术研究郑启仲教授治疗儿童抽动障碍的用药规律。方法以郑启仲教授治疗儿童抽动障碍的395首原始处方作为研究对象,对处方中药物的使用频次、性味归经频次进行统计分析,运用关联规则、复杂熵聚类提取出常见药物组合,并进行中医证型分析。结果处方共涉及199味中药,出现频次位于前10位的依次是白芍、僵蚕、蝉蜕、甘草、全蝎、天麻、谷精草、白附片、片姜黄、龙骨;性味归经以性寒、平、温,味甘、辛、苦以及归肝、肺、脾经为主;药物间关联度居前3位的依次为蝉蜕、僵蚕,白芍、甘草,白芍、蝉蜕、僵蚕;复杂熵聚类发现10个药物组合;中医证型分析以痰热动风、阴虚阳亢证最为常见。结论郑启仲教授认为儿童抽动障碍的基本病机为气机失调、升降失常,临证治疗以"和法"为主,升降同用、寒温并举,达到升清降浊、调畅气机的目的。

Objective Data mining technology was used to study professor ZHENG Qizhong’s medicine law in treating children with tic disorder.Methods The research object were 395 original prescriptions which professor ZHENG Qizhong used to treat children with tic disorders.The frequency of usage,frequency of flavour and meridian tropism of drugs in the prescription were statistically analysed,and association rules and complex entropy clustering were used to extract common drug combinations,and TCM syndrome type was analyzed.Results A total of 199 flavors of Chinese materia medica were involved in the prescription,and the frequency of occurrence in the top 10 is in the order of Baishao(Paeoniae radix Alba),Jiangcan(Bombyx batryticatus),Chantui(Cicadae periostracum),Gancao(Glycyrrhizae radix et rhizoma),Quanxie(Scorpio),Tianma(Gastrodiae rhizoma),Gujingcao(Eriocauli flos),Baifuzi(Typhonii rhizoma),Pianjianghuang(Wenyujin rhizoma concisum)and Longgu(Os draconis).The flavor and meridian tropism focused on cold,calming,warm property,the sweet,pungent,bitter flavors as well as liver,lung and spleen meridians.Degree of association between drugs in the top 3 in turn was Chantui(Cicadae periostracum),Jiangcan(Bombyx batryticatus);Baishao(Paeoniae radix Alba),Gancao(Glycyrrhizae radix et rhizoma);Baishao(Paeoniae radix Alba),Chantui(Cicadae periostracum),Jiangcan(Bombyx batryticatus).Ten drug combinations were found by complex entropy clustering.Phlegm-heat stirring wind and hyperactivity of yang due to asthenia of yin were the most common TCM syndrome type analysis.Conclusion Professor ZHENG Qizhong holds that the basic pathogenesis of children with tic disorder is disorder of qi movement and disturbance in ascending and descending.Thus the clinical treatment focuses on harmonizing therapy,simultaneous use of ascending and descending drugs as well as cold and warm drugs,achieving the purpose of ascending lucidity and descending turbidity and regulating qi movement as well.