糖皮质激素在治疗气管支气管结核中的应用进展

Research progress on glucocorticoids application in treatment of patients with tracheobronchial tuberculosis

目前,糖皮质激素(glucocorticoids,GCS)在治疗气管支气管结核(tracheobronchial tuberculosis,TBTB)中的作用仍存在争议和矛盾。一些研究发现,TBTB活动阶段的治疗目标是控制感染和预防气管支气管狭窄。早期TBTB炎症活动阶段可以通过短期使用吸入型糖皮质激素(inhaled corticosteroids,ICS)以控制炎症、减轻症状、预防支气管狭窄,但需警惕和严密监测ICS-TB相关性肺炎、非结核分枝杆菌性肺病、肺癌发生的可能。

There are still disputes and contradictions about the role of glucocorticoids(GCS)in the treatment of tracheobronchial tuberculosis(TB).Some studies found that the treatment for the patients with active tracheobronchial TB aimed to control infection and prevent tracheobronchial stenosis.At the early stage of inflammatory in the patients with active with tracheobronchial TB,inhaled corticosteroids(ICS)can be used to control inflammation,relieve symptoms and prevent bronchostenosis.However,the possibility of occurrence of ICS-TB-related pneumonia,nontuberculous mycobacterial pulmonary disease or lung cancer need to be vigilant and closely monitored.