高脂血症对心肌缺血再灌注损伤的影响

The effect of hyperlipidemia on myocardial ischemia-reperfusion injury

高脂血症是诱导缺血性心脏疾病发生发展的主要危险因素之一,除诱导动脉粥样硬化外,高脂血症还能直接导致心肌中氧化应激、炎症、凋亡增加及线粒体功能障碍等负面影响。高脂血症会丧失缺血预适应和后适应心肌保护作用,至少包括一氧化氮合酶功能减低,再灌注挽救激酶信号通路钝化,线粒体KATP开放通道和MPTP调节受损以及凋亡通路激活等参与其中的调节。

Hyperlipidemia is one of major risk factors for the occurrence and progression of ischemic heart disease,induces the development of atherosclerosis,has direct negative effects on the myocardium itself,including increasing levels of oxidative stress,inflammation,apoptosis and mitochondrial dysfunction.Moreover,hyperlipidemia abrogates the cardioprotective effects of ischemic preconditioning(IPC)and ischemic postconditioning(IPoC).Although not fully elucidated,the underlying mechanisms for the lost cardioprotection in hyperlipidemic animals have been reported to involve in dysregulation of the endothelial NOS,inactivation of reperfusion injury salvage kinase,modulation of ATPsensitive potassium channels and MPTP opening,and activation of apoptotic pathways.