综合分析阿托西班与利托君治疗高龄孕妇先兆早产临床疗效评价

Comprehensive Analysis of Atoxiban and Ritojun in the Treatment of Threatened Preterm Labor in Elderly Pregnant Women

目的分析阿托西班与利托君治疗高龄孕妇先兆早产的临床价值。方法方便选取该院2017年12月—2018年12月收取的100例先兆早产高龄孕妇者,以简单随机法分为研究组和对照组各50例,研究组予以阿托西班治疗,对照组予以利托君治疗,对两组的不良反应发生率、治疗有效率以及围生儿结局(新生儿窒息、体质量小于1000 g、体质量小于2000 g以及围生儿死亡)做观察比较。结果研究组患者治疗后引发皮肤瘙痒1例、产后出血0例、头疼1例、恶心呕吐0例、眩晕1例、心悸1例,总不良反应发生率为4例(8.00%),明显低于对照组,两组比较差异有统计学意义(χ^2=4.76,P<0.05);研究组2 d内治疗有效率为42例(84.00%)高于对照组32例(64.00%),7 d内治疗有效率研究组为45例(90.00%)、对照组为44例(88.00%)(χ^2=5.20,P<0.05;χ^2=0.10,P>0.05);研究组新生儿窒息、体质量小于1000 g的发生率小于对照组,两组比较差异有统计学意义(P<0.05),体质量小于2000 g、围生儿死亡的发生率比较差异无统计学意义(P>0.05)。结论阿托西班与利托君治疗高龄孕妇先兆早产均具有较好的临床疗效,但是运用阿托西班治疗在2 d内效果更佳,并且能够有效的降低孕妇的不良反应发生率,临床价值更为显著。

Objective To analyze the clinical value of Atoxiban and Ritojun in the treatment of threatened preterm labor in elderly pregnant women.Methods canvenient seleet 100 cases of threatened preterm pregnant women collected in the hospital from December 2017 to December 2018 were randomly divided into the study group and the control group,50 cases in each group.The study group was treated with Atoxiban and the control group was treated with Ritojun.The incidence of adverse reactions,treatment efficiency and perinatal outcomes(Neonatal asphyxia,body mass less than 1000 g,body mass less than 2000 g and perinatal death)were observed and compared.Results In the study group,1 case of skin itching,0 case of postpartum hemorrhage,1 case of headache,0 case of nausea and vomiting,1 case of vertigo,and 1 case of palpitations were treated.The incidence of total adverse reactions was 4 cases(8.00%),which was significantly lower than that of the control group.The difference between the two groups was statistically significant(χ^2=4.76,P<0.05).The effective rate of treatment in the study group was 42 cases(84.00%),32 cases(64.00%)higher than the control group,and the treatment efficiency within 7 days.There were 45 cases(90.00%)in the study group and 44 cases(88.00%)in the control group(χ^2=5.20,P<0.05;χ^2=0.10,P>0.05).Neonatal asphyxia,the incidence of body mass less than 1000 g was lower than that of the control group.The difference between the two groups was statistically significant(P<0.05),the body mass was less than 2000 g,and the incidence of perinatal death was not statistically significant(P>0.05).Conclusion Atoxiban and Ritojun have good clinical efficacy in the treatment of threatened preterm labor in elderly pregnant women,but Atoxiban has better effect in 2 days,and can effectively reduce the incidence of adverse reactions of pregnant women,with more significant clinical value.