康柏西普对病理性近视脉络膜新生血管患者血流动力学的影响研究

Study of the Effect of Conbercept on Hemodynamics in Patients with Pathological Myopia Choroidal Neovascularization

目的:探讨临床治疗病理性近视脉络膜新生血管的可靠方法,为临床实践提供参考依据。方法:选取2018年7-12月笔者所在医院临床收治的病理性近视脉络膜新生血管患者61例,给予患者玻璃体腔注射康柏西普治疗,对患者治疗前后的视网膜血流动力学指标(PSV、EDV、RI)、血清炎症因子指标(IL-1、IL-6和IL-8)、最佳矫正视力(BCVA)和黄斑中心凹视网膜的厚度(CMT)进行观察和比较。结果:治疗后患者的PSV和EDV均明显升高,RI指标明显降低,治疗前后比较差异有统计学意义(P<0.05);治疗后患者的IL-1、IL-6和IL-8均明显降低,治疗前后比较差异有统计学意义(P<0.05);治疗后患者的BCVA明显升高,CMT明显降低,治疗前后比较差异有统计学意义(P<0.05)。结论:采用玻璃体腔注射康柏西普治疗病理性近视脉络膜新生血管能够有效改善患者视网膜血流动力学指标,降低局部炎症反应过程,提升患者最佳矫正视力,降低黄斑中心凹视网膜厚度,临床综合效果显著,是临床治疗病理性近视脉络膜新生血管的可靠方案之一。

Objective: To explore the reliable method for clinical treatment of pathological myopia choroidal neovascularization, and to provide reference for clinical practice. Method: A total of 61 patients with pathological myopia choroidal neovascularization admitted to our hospital from June to December 2018 were chosen. The patients were treated with vitreous injection of Conbercept. The retinal hemodynamic parameters(PSV, EDV, RI), serum inflammatory factor index(IL-1, IL-6, IL-8), best corrected visual acuity(BCVA) and thickness of the foveal fovea(CMT) were observed and compared before and after treatment.Result: After treatment, the PSV and EDV were significantly increased, and the RI index was significantly lower. The differences were statistical significance before and after treatment(P<0.05). The patients’ IL-1, IL-6 and IL-8 were reduced significantly after treatment, and the differences before and after treatment were statistical significance(P<0.05). The BCVA of the patients was significantly increased and the CMT was significantly decreased after treatment. The differences were statistical significance before and after treatment(P<0.05). Conclusion: Intravitreal injection of Conbercept in the treatment of pathological myopia choroidal neovascularization can effectively improve the retinal hemodynamic parameters, reduce the local inflammatory reaction process, improve the best corrected visual acuity, reduce the foveal retinal thickness of the fovea, the clinical comprehensive effect is remarkable, and it is one of the reliable solutions for clinical treatment of pathological myopia choroidal neovascularization.