摘要
哮喘是一种异质性综合征,是影响全球3亿多人的呼吸道慢性炎症性疾病,有不同的临床表现和表型,嗜酸性哮喘是严重哮喘最常见的表型;呼出气一氧化碳(fractional exhaled nitric oxide,FeNO)是一种无创、易于获得的生物标志物,被认为是预测哮喘发展和恶化、识别特定哮喘表型的一种生物标志物,在具有较高的敏感性与特异性,在ATS指南中,建议使用FeNO诊断嗜酸性气道炎症并确定对类固醇反应。本篇综述对FeNO与成人哮喘的关系及研究进展做简要总结。
Asthma is a heterogeneous syndrome,a chronic inflammatory respiratory disease affecting more than 300 million people worldwide,with different clinical manifestations and phenotypes.Eosinophilic asthma is the most common phenotype of severe asthma.FeNO is a noninvasive and readily available biomarker that is considered to predict the development and progression of asthma and identify specific asthma phenotypes.With high sensitivity and specificity,it is recommended to use FeNO in the ATS guidelines to diagnose eosinophilic airway inflammation and to determine the response to steroids.This review summarizes the relationship between FeNO and adult asthma and the research progress.
作者
卢敏燕
马礼兵
LU Minyan;MA Libing(Department of Respiratory Medicine,the Affiliated Hospital of Guilin Medical University,Institute of Respiratory Diseases,Guilin Medical University,Key Laboratory of Respiratory Diseases of Colleges and Universities Affiliated Education Department of Guangxi Zhuang Autonomous Region,Guilin 541001,China)
出处
《实用医学杂志》
CAS
北大核心
2019年第23期3708-3711,共4页
The Journal of Practical Medicine
基金
国家自然科学基金项目(编号:81360006,81560007,81760009)