双歧三联活菌对溃疡性结肠炎伴抑郁患者抑郁症状的治疗效果

Therapeutic effect of bifid triple viable bacteria on depressive symptoms in patients with ulcerative colitis and depression

目的探讨双歧三联活菌对溃疡性结肠炎(ucerative colitis,UC)伴抑郁患者抑郁症状的治疗效果。方法选取2018年1月至2019年2月期间在我院接受治疗的UC伴抑郁患者112例,根据随机数字表法将患者分为对照组(56例)和研究组(56例)。对照组采用氟哌噻吨美利曲辛片与美沙拉秦进行治疗,研究组在此基础上联用双歧三联活菌进行治疗。比较两组患者的临床疗效、Mayo评分、抑郁自评症状表(SDS)评分、肠道菌群、炎症因子[肿瘤坏死因子-ɑ(TNF-ɑ)、白介素-6(IL-6)]和不良反应。结果研究组的总有效率高于对照组,但比较差异无统计学意义(P>0.05),研究组的缓解率高于对照组(P<0.05);治疗2个月后,研究组患者的Mayo评分、SDS评分、血清TNF-ɑ、IL-6均低于对照组(P<0.05);治疗2个月后,研究组患者的大肠埃希菌、梭菌属、拟杆菌属数量低于对照组,乳酸菌属、双歧杆菌属数量高于对照组(P<0.05);两组患者的不良反应发生率比较差异无统计学意义(P>0.05)。结论双歧三联活菌治疗UC伴抑郁患者可有效调节患者的肠道菌群、减轻炎症反应,改善患者的抑郁症状,且不良反应少而轻微。

Objective To investigate the therapeutic effect of bifid triple viable bacteria on depressive symptoms in patients with ulcerative colitis(UC)and depression. Methods 112 patients with UC and depression who were treated in our hospital from January 2018 to February 2019 were enrolled. The patients were randomized into control group(56 cases)and study group(56 cases)according to the random number table. The control group was treated with Flupentixol and Melitracen Tablets and mesalazine. The study group was treated with bifid triple viable bacteria on the basis of the control group. The clinical efficacy,Mayo score,Self-rating depression scale(SDS)score,intestinal flora,inflammatory factor[tumor necrosis factor-ɑ(TNF-ɑ),interleukin-6(IL-6)]and adverse reactions were compared between the two groups. Results The total effective rate of the study group was higher than that of the control group,but the difference was not statistically significant(P > 0.05). The remission rate of the study group was higher than that of the control group(P < 0.05). After 2 months of treatment,the Mayo score,SDS score,serum TNF-ɑ and IL-6 of the study group were lower than those of the control group(P < 0.05).Meanwhile,the number of Escherichia coli,Clostridium and Bacteroides of the study group was lower than that of the control group,and the number of lactic acid bacteria and Bifidobacterium was higher than that of the control group(P < 0.05). There was no significant difference in the incidence of adverse reactions between the two groups(P > 0.05). Conclusion Bifid triple viable bacteria therapy for UC patients with depression can effectively regulate the intestinal flora,reduce the inflammatory response,and improve the depressive symptoms of patients along with few and slight adverse reactions.