胰腺癌肝转移的分子机制研究进展

Research progress about the molecular mechanism of liver metastasis from pancreatic cancer

胰腺癌是一种具有侵袭性的恶性肿瘤,患者5年生存率不到5%。患者常在就诊时已处于晚期或发生转移,肝脏是其最常见的转移部位,以致预后与治疗不容乐观。近年来胰腺癌肝转移的生物学特性也引起了人们的重视,本文就胰腺癌肝转移过程的前沿研究进展进行重点阐述,以期更全面地了解其分子调控机制,为今后胰腺癌肝转移的综合性诊治及预后评价提供理论依据。

Pancreatic cancer is an aggressive malignancy with an five-year survival rate of less than 5%.Patients often present with advanced or even metastasized disease,and the liver is the main site of metastasis,which leads to the poor prognosis and treatment. Recently,the biological characteristics of liver metastasis of pancreatic cancer have also attracted people′s attention. This review focuses on the research advances in the process of liver metastasis of pancreatic cancer,in order to get a better understanding of the molecular regulation mechanism of liver metastasis of pancreatic cancer and provide basis for comprehensive diagnosis,treatment and prognosis evaluation in the future.