动物干扰素研究概况

Progress on Animal Interferons

随着我国养殖业的迅猛发展,各种疾病的发生和危害日益加重,特别是病毒性疫病,已成为传染病的主体。对于病毒性疾病的治疗仍然缺乏有效的药物,且大多数尚无效果可靠的疫苗,再加上新发和再发病不断出现,使得病毒病危害尤为突出,急待寻找提高机体免疫、抵抗病毒感染的替代药物。干扰素(IFN)作为一种细胞因子具有广谱抗病毒、抗肿瘤和免疫调节活性,还可以促进机体免疫反应,提高机体抗病毒感染能力,使病毒在机体存活和复制的几率降到最低。目前发现Ⅰ型、Ⅱ型和Ⅲ型3种类型的IFN,利用3种类型的IFN的抗病毒和调节免疫的功能,研究抑制病毒复制的新型生物制剂,成为人们关注和研究的热点,为病毒性疫病,特别是新发或突发的重大疫病防控提供参考。

Viruses have become the major pathogens of infectious diseases.However,there is still a lack of effective drugs or vaccine to contain viral diseases.It is urgent to find alternatives which can improve the host immunity and help to resist viral infections.IFN is an important cytokine which is characteristic with wide spectrum antiviral, antitumor,and immune regulation activities.At present, three types of IFNs of type Ⅰ,type Ⅱ and type Ⅲ have been discovered with different activities.The use in inhibiting viral replication has attracted attentions.In this review the activities of 3 types of IFN are discussed and supply information for the using of IFN in viral disease.